Michael Additions of Indoles to Conjugate Systems by Various Acid Catalysts

Michael Additions of Indoles to Conjugate Systems by Various Acid Catalysts 

Product Time (days) Yield (%) Pressure (kbar) Catalyst 

Nevertheless, Michael acceptors such as phenyl vinylsulfone, ethyl cinna-mate, methyl acrylate, acrylonitrile and a, 3-unsaturated aldehydes failed to react in the reaction catalyzed by Yb(OTf)3 3H2O. 

The (i-carbolinc skeleton with its 9H-pyrido[ 3,4-fr ]indole (29) is frequently encountered in pharmacology due to its activity in the central nervous system at serotonin receptors. It also shows prominent biological properties at the benzodiazepine receptor (BzR) [45]. ZK 93423 (30) remarkably amplifies the agonist activity of such compounds towards BzR. 1,2,3 9-Telrahydro-( -carbolines are common precursors of (i-carbolines [46]. 1,3.4,9-Tetrahydro- 

The natural product asterriquinone Al (41) and asterriquinone derivatives containing the 3-indolylbenzoquinone structure exhibit a wide spectrum of biological activities, including antitumor properties, inhibition of HIV reverse transcriptase and as an orally active nonpeptidyl mimetic of insulin 

---