Micelles polymeric , dendritic

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Synthetic glycopolymers of various architectures have been prepared in recent years using the fast development of controlled polymerization techniques and the very efficient coupling reactions in polymer analogous approaches. Both, linear and globular polymer structures that have been obtained by synthesizing dendritic, starlike, or micelle-like structures or nanogels have received much attention. 

One of the emerging strategies to overcome the drawbacks of dendrimers and dendritic nanomaterials is their hybridization with other types of nanoparticles, which is most commonly used in targeted cancer drug delivery. The tumor characteristic of enhanced permeability and retention (EPR) effect allows polymeric nanoparticles, micelles, and liposomes of relatively large size (typically 50-200 nm in diameter) to be selectively accumulated in tumor sites.[32] This size-based accumulation in tumor sites, called passive targeting, cannot be easily exploited by dendrimers due to their small size (<10 nm). In contrast, active... 

The vast range of supramolecular polymeric materials also extends from the use of small molecules (e.g., double-sided discotics or multifunctional monomers with a discrete tether) to very large molecules (polymeric or dendritic). Another important characteristic of SPs is the timescale upon which the chains exist, which is defined by the rate of association/ dissociation of the monomers. Tme dynamic SPs must be reversible (breaking and recombining) on experimental time-scales (e.g., NMR timescale). A physical model developed by Cates and co-workers predias many viscoelastic properties of SPs as a funaion of the strength of the noncovalent interactions existing between monomers.Although initial studies focused on wormlike micelles, the model has been demonstrated to successfully describe the viscosity behavior of reversible, self-complementary UPy-based SPs. ... 

Wooley and coworkers utilized click chemistry to prepare block copolymer micelles and shell cross-linked nanoparticles (SCKs) presenting click-reactive functional groups on their surfaces [144,145]. Moreover, they presented the preparation of well-defined core cross-linked polymeric nanoparticles, utilizing multifunctional dendritic cross-linkers that allow for the effective stabilization of supramolecular polymer assemblies and the simultaneous introduction of reactive groups within the core domain [146]. 

Investigation of the possible applications of dendrimers has been limited by their lack of ready availability [14]. It is anticipated that dendrimers may be used as a polymeric matrix for catalysts, as a membrane for gas separation, and as part of the diagnostic kit for MRI since many groups can be added to the core or to the periphery. The unique structure and solubility characteristics of dendrimers suggest that their use as dendritic micelles may be important. In addition, they may form interesting and useful monolayers [14]. 

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