Echinocandins micafungin

Echinocandin = caspofungin 70 mg loading dose, then 50 mg IV daily maintenance dose, or micafungin 100 mg daily, or anidulafungin 200 mg loading dose, then 100 mg daily maintenance dose. 

Joseph JM, Jain R, Danziger LH. (2007) Micafungin Anew echinocandin antifungal. Pharmacotherapy 27 53-67. 

Pharmacology Micafungin is a semisynthetic lipopeptide (echinocandin) synthesized by a chemical modification of a fermentation product of Coleophoma empetri F-11899. Micafungin inhibits the synthesis of 1,3- -D-glucan, an essential component of fungal cell walls, which is not present in mammalian cells. Pharmacokinetics ... 

The echinocandins were the first new antifungal drug class to be introduced in more than 15 years (Figure 15.2). The first echinocandin product to be marketed was caspofungin acetate (Cancidas, Merck), followed by micafungin [Funguard (Japan) and Mycamine (other countries), Fujisawa] and... 

FR901379 (isolated from the fungus Coleophoma empetri) and echinocandin B (isolated from Aspergillus nidulans) led to two additional clinical agents of this class, micafungin (41) and anidulafungin (42), respectively. (16, 17)... 

Micafungin Sodium EUNGUARD 2002 antifungal Fujisawa Echinocandin 15 derivative (fungus)... 

Echinocandins In a phase I study of the effects of posaconazole on the pharmacokinetics of caspofungin and micafungin in 67 healthy subjects no interaction was observed. Adverse events, clinical laboratory tests, vital signs, and electrocardiograms were unaffected [16 ]. 

Tamura K, Urabe A, Yoshida M, Kanamaru A, Kodera Y, Okamoto S, Maesaki S, Masaoka T. Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders. Leuk Lymphoma 2009 50 92-100. 

Groll, A.H. Miokiene, D. Petraitis, V. Petraitiene, R. Ibrahim, K.H. Piscitelli, S.C. Bekersky, I. Walsh, T.J. Compartmental pharmacokinetics and tissue distribution of the antifungal echinocandin lipopeptide micafungin (FK463) in rabbits, Antimicrob.Agents Chemother., 2001, 45, 3322-3327. 

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