Phenprocoumon Mianserin

Also analyzed acebutolol, acetaminophen, alprazolam, amphetamine, atenolol, betaxolol, brotizolam, caffeine, camazepam, captopril, chloroquine, clobazam, clomipramine, cloth-iapine, clotiazepam, cloxazolam, cocaine, codeine, diclofenac, dihydralazine, dihydrocodeine, dihydroergotamine, diphenhydramine, domperidone, doxepin, droperidol, ergota-mine, ethyl loflazepate, fenethylline, fluoxetine, flupentixol, flurazepam, furosemide, gliclazide, hydrochlorothiazide, hydroxyzine, ibuprofen, imipramine, ketazolam, loprazo-1am, lorazepam, lormetazepam, maprotUine, medazepam, mepyramine, methadone, methaqualone, methyldopa, methylphenidate, metoclopramide, metoprolol, mexiletine, mianserin, midazolam, minoxidil, morphine, nadolol, nitrazepam, oxprenolol, papaverine, pentazocine, phenprocoumon, phenylbutazone, pipamperone, piritramide, practolol, pra-zepam, prazosin, promazine, promethazine, propoxyphene, propranolol, prothipendyl, quinine, sotalol, sulpride, thioridazine, trazodone, triazolam, trimipramine, tripelennamine, lyramine, verapeunil, yohimbine... 

In one study mirtazapine caused a slight increase in INR in subjects given warfarin. In studies in patients, maprotiline did not alter the anticoagulant effect of acenocoumarol, and mianserin did not alter the anticoagulant effect of phenprocoumon. In isolated case reports, an increased effect of warfarin and a decreased effect of acenocoumarol was seen when mianserin was given. 

In a randomised, double-blind study in 60 patients taking phenprocoumon for 5 weeks, there was no difference in anticoagulant control and phenprocoumon dose between placebo recipients and those receiving either mianserin up to 30 mg daily or up to 60 mg daily for 20 days. ... 

Maprotiline does not interact with acenocoumarol and mianserin does not interact with phenprocoumon. The isolated cases of an increase in warfarin effects and a decrease in acenoeoumarol effects with mianserin are unexplained, and probably of little general relevance. One UK manufacturer of mirtazapine very eautiously advises that the prothrombin time should be controlled if mirtazapine is given with warfarin. However, there do not appear to be any reports of problems with this combination, and another manufacturer does not consider monitoring to be necessary. ... 

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See also in sourсe #XX -- [ ]

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