Metoclopramide dosage

Renal/Hepatic function impairment Because metoclopramide is excreted principally through the kidneys, in those patients whose Ccr is less than 40 mL/min, initiate therapy at approximately >2 the recommended dosage. Depending on clinical efficacy and safety considerations, the dosage may be increased or decreased as appropriate. 

Children Infants and children (21 days to 3.3 years of age) with symptomatic gastroesophageal reflux have been treated with metoclopramide at a dosage of 0.5 mg/kg/day symptoms improved, the duration of the disease was shortened, and surgery was avoided. 

Inadequate antiemetic dosage Mrs CR is currently taking metoclopramide as a... 

The absorption of oral dantrolene can be significantly increased by metoclopramide (15). As the risk of hepatotoxicity has been related to the dosage of dantrolene, increased clinical surveillance is necessary to avoid toxicity of dantrolene during concurrent treatment with metoclopramide. 

Metoclopramide pre-treatment reduces the dosage requirements of propofol and thiopental. Droperidol, but not ondansetron, reduces the dose requirements of thiopentaL... 

When 14 kidney transplant patients were given metoelopramide their peak ciclosporin blood levels were ineieased by 46%, from 388 to 567 nanograms/mL and the ciclosporin AUC was increased by 22%. The dosage of metoclopramide was 10 mg by mouth 30 minutes before, 5 mg with, and 5 mg 30 minutes after the morning dose of ciclosporin. Ciclosporin is largely absorbed by the small intestine so the likely mechanism for this interaction is increased absorption of ciclosporin because metoclopramide hastens gastric emptying. The clinical importance of this interaction is uncertain. Concurrent use should be well monitored to ensure that any increase in ciclosporin peak levels does not increase adverse effects. Note that the increase in the AUC of ciclosporin is only modest. 

Absorption of digoxin in the stomach may be diminished. Absorption of oral medication (e.g. acetaminophen, levodopa, tetracycline, and ethanol) in the small bowel may be increased. Insulin dosage may require adjustment because the action of metoclopramide will influence the dehvery of food to the intestines and thus the rate of absorption. Metoclopramide increases the effect of succinylcholine and the serum levels of cyclosporine. 

---