Methylprednisolone Rifampicin

Clinically important, potentially hazardous interactions with aprepitant, astemizole, carbamazepine, colchicine, cyclosporine, dihydroergotamine, ergot alkaloids, ergotamine, erythromycin, fluoxetine, fluvoxamine, methylprednisolone, methysergide, oral contraceptives, paroxetine, pimozide, prednisolone, rifampicin, sertraline, solifenacin, terfenadine, warfarin... 

The effects of systemic cortisone, dexamethasone, fludrocortisone, hydrocortisone, methylprednisolone, prednisone and prednisolone can be markedly reduced by rifampicin, but aldosterone appears not to be affected. Rifabutin and rifapentine are predicted to interact similarly, all be it to a lesser extent. 

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