4-Methylphenyl isothiocyanate

Phenyl isothiocyanate 4-Nitrophenyl isothiocyanate Trifluoromethyl phenyl isothiocyanate 4-Cyanophenyl isothiocyanate 4-Methoxyphenyl isothiocyanate 4-Fluorophenyl isothiocyanate 4-Methylphenyl isothiocyanate 2-Fluoro-5-(trifluoromethyl)phenyl isothiocyanate 4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate 4-Fluoro-3-(trifluoromethyl)phenyl isothiocyanate 3,5-Bis(trifluoromethyl)phenyl isothiocyanate 1,4-Phenylene diisothiocyanate... 

C9H9CI02 2-chloromethyl-p-anisaldehyde 73637-11-3 491.59 43.076 2 16418 C9H9NOS 2-methoxy-5-methylphenyl isothiocyanate 190774-56-2 561.15 49.789 1,2... 

The amount of isothiocyanate formed on irradiation of 5-phenylthiatriazole is remarkably independent of the conditions employed.20 In a number of solvents, yields of 6.0-7.696 were found at room temperature. At 193°K the yield was 4.6—4.8% in methylene chloride. 5-(2-Methylphenyl)-l,2,3,4-thiatriazole behaved similarly, giving rise to 7.6% isothiocyanate. This insensitivity of the yield of isothiocyanate under various photolytic conditions is believed virtually to rule out nitrene intermediates. Furthermore, characteristic nitrene products were sought for in the photolysis mixture but not found. ESR spectroscopy also failed to provide evidence for the intermediacy of a thioacyl nitrene (10). 

N-[3 -(4-Methy Iphenyl)-1 -phenyl-1 H-pyrazol-4-methylidene] -cyanoacetic acid hydrazide 154 was synthesised in an excellent yield by condensing 3-(4-methylphenyl)- -phenyl-lH-pyrazole-4-carboxaldehyde with cyano-acetic acid hydrazide. This intermediate was converted to the 4-amino-3-aryl-5-[3-(4-methylphenyl)-1 -phenyl-1 H-pyrazol-4-methylidenehydrazinocarbonyl] -thiazole-2(3H)-thiones 155 (Scheme 72), following the method described by Gewald, it involved the reaction of the cyanoacetic acid hydrazide derivative 154 with sulphur and the appropriate aryl isothiocyanate in the presence of triethylamine as a basic catalyst. Cyclisation of 145 to the 3-aryl-6-[3-(4-methylphenyl)-l-phenyl-1 H-pyrazol-4-methylideneamino] -2-thioxo-2,3 -dihydrothiazolo [4,5 -djpyrimidin-7(6H)-ones 156 was achieved by heating the former with a mixture of triethyl orthoformate and acetic anhydride (1 1) [4],... 

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