4- Fluorophenyl isothiocyanate

Fluorophenyl isothiocyanate [1544-68-91 M 153.2, m 24-26 , 26-27 , b 66 /2mm, 215 /atm, 228 /760mm, n 1.6116. Likely impurity is the symmetrical thiourea. Dissolve the isothiocyanate in dry CHCI3, filter and distil the residue in a vacuum. It can also be steam distd, the oily layer separated, dried over CaCl2 and distilled in vacuo. Bis-(4-fluorophenyl)thiourea has m 145 (from aq EtOH). [Browne and Dyson J Chem Soc 3285 1931 Buu Hoi et al. J Chem Soc 1573 1955 Olander Org Synth Coll Vol I 448 1941 ]. 

Phenyl isothiocyanate 4-Nitrophenyl isothiocyanate Trifluoromethyl phenyl isothiocyanate 4-Cyanophenyl isothiocyanate 4-Methoxyphenyl isothiocyanate 4-Fluorophenyl isothiocyanate 4-Methylphenyl isothiocyanate 2-Fluoro-5-(trifluoromethyl)phenyl isothiocyanate 4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate 4-Fluoro-3-(trifluoromethyl)phenyl isothiocyanate 3,5-Bis(trifluoromethyl)phenyl isothiocyanate 1,4-Phenylene diisothiocyanate... 

Direct and indirect chromatographic methods were developed and compared in systematic examinations for the enantioseparation of P-amino acids direct separation of underivatized analytes involved the use of commercially available Crownpak CR(-I-), teicoplanin, and ristocetin A CSPs [148], while indirect separation was based on precolumn derivatization with 2,3,4,6-tetra-G-acetyl-f)-D-glucopyranosyl isothiocyanate (GITC) or A - a-(2,4-dinitro-5-fluorophenyl)-L-alaninamide (EDAA, Marfey s reagent), with subsequent separation on a nonenantioselective column. 

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