4-Methoxyphenyl isothiocyanate

A suspension of the Step 7 product (0.0135 mol) in 60 ml toluene was treated with the dropwise addition of 4-methoxyphenyl isothiocyanate (13.5 mmol) and the mixture stirred 3 hours at ambient temperature. A white precipitate that formed was removed by filtration and washed with toluene and diethyl ether. The solid was recrystallized from acetone and the product isolated in 79% yield as a white solid, mp = 184-187°C. 

Phenyl isothiocyanate 4-Nitrophenyl isothiocyanate Trifluoromethyl phenyl isothiocyanate 4-Cyanophenyl isothiocyanate 4-Methoxyphenyl isothiocyanate 4-Fluorophenyl isothiocyanate 4-Methylphenyl isothiocyanate 2-Fluoro-5-(trifluoromethyl)phenyl isothiocyanate 4-Methyl-3-(trifluoromethyl)phenyl isothiocyanate 4-Fluoro-3-(trifluoromethyl)phenyl isothiocyanate 3,5-Bis(trifluoromethyl)phenyl isothiocyanate 1,4-Phenylene diisothiocyanate... 

Methoxyphenyl isothiocyanate 1-lsothiocyanato-2-methoxy- benzene CsHjNOS 3288-04-8 165.213 264 1.1878"" 1.6458"" ... 

Triazolo[3,4-6] 1,3-benzoxazole-3-thione (85) has been prepared by cyclizing 2-hydrazino-l,3-benzoxazole (83) with carbon disulfide (58USP2861076) or phenyl isothiocyanate (59JOC1478). The alternative approach (62TL1193) of fusing the 1,3-benzoxazole onto a 1,2,4-triazole was also used in the synthesis of 3-phenyl-1,2,4-triazolo[3,4- ]-benzoxazole (88) from 3-hydroxy-5-phenyl-4-(2-methoxyphenyl)-1,2,4-triazole (86). 

A similar reaction of the heterocycle 168 with two equivalents of 4-methoxyphenyl isoselenocyanate affords the tetrazathiapentalene 170. The initially formed 1 1 cycloadduct 169 eliminates methyl isothiocyanate, followed by reaction with the second equivalent of... 

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