Methylhydroxypropyl cellulose

Lippold, B.C. Mockel, J.E. Pulsatile release from laminated methylhydroxypropyl cellulose matrices with KCl as model drug. Acta Pharm. Technol. 1990, 36 (2), 97-98. 

Cellulosic thickeners are among the most commonly used thickeners for decorative latex-based paints. They are produced by chemical modifications of cellulose such as carboxymethylation or etherification. The most widely used derivatives are hydroxyethyl cellulose, ethylhydroxyethyl cellulose, methylhydroxyethyl cellulose, methylhydroxypropyl cellulose, and sodium carboxymethyl cellulose. The important characteristics that control the properties of different grades of individual derivatives are degree of polymerization, degree of substitution and molar substitution. 

Methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, caiboxymethyl cellulose, ethylhydroxyethyl cellulose, methylhydroxypropyl cellulose... 

In many applications and formulations, WSPs with surface-active properties are desirable. These properties are imparted to a polymer by chemical modification of the hydrophilic WSP with appropriate hydrophobic substituents. Examples of commercially available surface-active WSPs based on cellulose include its methyl, hydroxypropyl, and methylhydroxypropyl derivatives. 

A systematic study has been made of the influence of the specific water structure and diphylic nature of some cellulose ethers (methyl-, methylhydroxypropyl-, hydroxypropyl-, hydroxyethyl-, and hydroxyethylhydroxypropyl-) on the properties of their aqueous solutions. " The presence of nonpolar groups in the cellulose ether macromolecule and of specific water structures account for the solution properties given by hydrophobic hydration and hydrophilic bonds. 

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