Methylglyoxal-bis

Distribution. The distribution of foreign compounds may vary between species because of differences in a number of factors such as proportion and distribution of body fat, rates of metabolism and excretion and hence elimination, and the presence of specific uptake systems in organs. For instance, differences in localization of methylglyoxal-bis-guanyl hydrazone (Fig. 5.6) in the liver account for its greater hepa to toxicity in rats than in mice. The hepatic concentration in mice is only 0.3% to 0.5% of the dose after 48 hours, compared with 2% to 8% in the rat. 

Table 5.6 Urinary Excretion of Methylglyoxal-bis-Guanylhydrazone in Mammalian Species...

Stanek, J., Caravatti, G., Capraro, H.-G., Furet, P, Mett, H., Schneider, P, Regenass, U. S-Adenosylmethionine decarboxylase inhibitors new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone). J. Med. Chem. 1993, 36, 46-54. 

TABLE 5.6 Urinary excretion of methylglyoxal-bis-guanylhydrazone in mammalian species... 

McCullough, J.L., Peckham, P, Klein, J., Weinstein, G.D., and Jenkins, J.J. (1985). Regulation of epidermal proliferation in mouse epidermis by combination of difluoromethyl ornithine (DEMO) and methylglyoxal bis(guanylhydrazone) (MGBG), J. Invest. Dermatol, 85 518-521. 

Kong, L. Attree, S.M. Fowke, L.C. (1998). Effects of polyethylene glycol and methylglyoxal bis(guanylhydrazone) on endogenous polyamine levels and somatic embryo maturation in white spruce Picea glauca). Plant Science, Vol. 133, No. 2, pp 211-220, ISSN 0168-9452. 

T. A. Donovan and J. C. Bailar, Jr, An Investigation of the Coordination Chemistry of Glyoxal-bis-(Guanylhydrazone) and Methylglyoxal-bis-(Guanylhydrazone), J. Inorg. Nuclear Chem. 26 1283 (1964). 

Gc.e-Bis-p-tolyIiiitta aniino.pentan 12, 984. [/J-Phenyl-liydrazmo]-layulm84iiM-4thyl ester-[ 8-phenyl-hydTazon] 15, 418. Methylglyoxal-bis- [4- thoxy-phenyl hyuazon] 15, 5M. II276. 

A. Schenone, Specific inhibition of the enzyme decarboxylation of S-adenosylmethionine by methylglyoxal bis (guanilhydrazone) and related substances, Biochem. J., 139 351 (1974). 

Abbreviations ADC, arginine decarboxylase ODC, ornithine decarboxylase SAM, 5-adenosylmethionine DFMA, DL-a-difluoromethylaiginine DFMO, DL-a-difluoromethyl-omithine MGBG, methylglyoxal bis(guanylhydrazone) DCHA, dicyclohexylamine. 

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