S-Adenosylmethionin-decarboxylase inhibitor

Stanek, J., Caravatti, G., Capraro, H.-G., Furet, P, Mett, H., Schneider, P, Regenass, U. S-Adenosylmethionine decarboxylase inhibitors new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone). J. Med. Chem. 1993, 36, 46-54. 

Hirth B, Barker RH Jr, Celatka CA, Klinger JD, Liu H, Nare B, Nijjar A, Phillips MA, Sybertz E, Willert EK, Xiang Y (2009) Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis (HAT). Bioorg Med Chem Lett 19(11) 2916-2919... 

Aminooxy compounds can be viewed as O-ethers of HA and are discussed here in terms of their potential anticancer activity. Thus, l-aminooxy-3-aminopropane (APA) is a potent reversible inhibitor of mammalian ornithine decarboxylase (ODC) and of S-adenosylmethionine decarboxylase (SAMDC) , and 6 -(5 -deoxy-5 -adenosyl)methylsul-fonium 0-ethylhydroxylamine (AMA) was reported to be an efficient reversible inhibitor of the latter enzyme . 

Ornithine decarboxylase is specifically inhibited by the enzyme-activated inhibitor a-difluoromethyl-ornithine, which can cure human infection with Trypanosoma brucei (African sleeping sickness) by interfering with polyamine synthesis.243-2443 In combination with inhibitors of spermidine synthase or S-adenosylmethionine decarboxylase,245 it can reduce polyamine levels and growth rates of cells. Another powerful inhibitor that acts on both ornithine and adenosylmethionine decarboxylases is the hydroxy-lamine derivative l-aminooxy-3-aminopropane 246... 

Bitonti, A. J., Byers, T. L., Bush, T. L. et al. (1990) Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase. Antimicrob. Agents. Chemother. 34 1485-1490. 

The cyclopentene derivative 82 has been prepared from 2, 3 -0-isopropylidene-5 -thioadenosine, and was an irreversible inhibitor of S-adenosylmethionine decarboxylase. ... 

Secrist, in a plenary lecture, has described the synthesis of new substrate analogues as inhibitors of S-adenosylmethionine decarboxylase. The compounds made were of type (31), where E is a... 

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