Methyldopate

Mannitol should neither be mixed with whole blood for transfusion nor be administered through the same sets by which blood is being infused. Visual incompatibilities are found when methyldopate hydrochloride is mixed with methohexitone sodium, amphotericin, tetracyclines, or sulfadiazine.119... 

Adrenaline, betanaphthol, dobutamine, dopamine, ethamivan, ethylnoradren-aline, hexylresorcinol, hydroquinone, hyd-roxyquinoline, isoetharine, isoprenaline, levodopa, methyldopa, methyldopate, noradrenaline, paraphenylenediamine, phenothiazine, protokylol, rimiterol... 

Dose. Usually 250 to 500 mg of methyldopate hydrochloride, by intravenous infusion, every 6 hours. 

Octamylamine Hydrochloride Arecoline Hydrobromide Isosorbide Dinitrate Carbazochrome Carbamazepine Cyclobarbitone Dropropizine Hexobarbitone Methazolamide Procaine Thiacetazone Tetrahydrozoline Hydrochloride Carbromal Cotarnine Viloxazine Ketamine Methyldopa Nitrofurantoin Proxyphylline Nealbarbitone Nomifensine Quinalbarbitone Isoetharine Methyldopate Salbutamol Benzphetamine Methacholine Bromide Danthron Cropropamide Hexethal... 

Methyldopate HCl (Aldomet ester HCl) IV infusion after dilution Sodium citrate 0.3% Citric acid 0.5% pH 3.5. 2... 

Dmgs that contain ester linkages include acetylsalicylic acid (aspirin), physostigmine, methyldopate, tetracaine and procaine. Ester hydrolysis is usually a bimolecular reaction involving acyl-oxygen cleavage. For example, the hydrolysis of procaine is shown in Scheme 4.2. 

Rgure 16-6 Metabolic conversion of methyldopate and f JtyIdopa to cr-methylnorepinephnne. 

Methyidopa is used only by oral administration. since its zwittcrionic character limits its solubility. Absorption can range from 8 to 62% and appears to involve an amino acid transporter. Absorption is affected by food, and about 40% of that absorbed is converted to methyIdopa-O-.suliate by the muco.sal intc.stinal cells. Entry into the CNS also appears to involve an active transport process. The ester hydrochloride salt of methyidopa. methyldopate (Aldomet ester), was developed as a highly water-soluble derivative that could be u.scd to make parenteral preparations. Methyldopate is converted to methyidopa in the body through the action of estera.ses (Fig. 16-6). 

Methyidopa is available in an oral dosage form (alone or in combination with a thiazide diuretic, hydrochlorothiazide) and a parenteral dosage form (methyldopate hydrochloride). 

Methyldopa tablets 250 mg methyldopa, tablets 500 mg methyldopa, methyldopate hydrochloride injection 50 mg/mL)... 

Ethyl e ter hydrochloride, C, H,8CIN04. methyldopate hydrochloride. After drying, mol wt 275.7 (] mg — 0.77 mg of the free acid). Soluble in water to the extent of 10-300 mg/ml at pH 2-7. May be stabilized with sodium bisulfite and/or disodium EDTA. 

Noninterfering dopamine, levodopa, methyldopa, methyldopate, norepinephrine... 

Noninterfering dopamine, levodopa, methyldopa, methyldopate, norepinephrine Interfering acetylcodeine, amphetamine, chlorphentermine, fencamfamin, fenfluramine, methylenedioxyamphetamine, monoacetylmorphine, norpseudoephedrine, phentermine, phenylpropanolamine, thebacon, thebaine... 

---