2-Methylbenzylethyldimethylammonium bromide

A. o-Methylbenzyl acetate. A solution of 29.8 g. (0.20 mole) of 2-methylbenzyldimethylamine 2 and 32.7 g. (0.30 mole) of ethyl bromide in 40 ml. of absolute ethanol is placed in a 500-ml. round-bottomed flask fitted with a reflux condenser capped with a calcium chloride drying tube. The solution is heated under reflux on the steam bath for 1 hour then an additional 10.8 g. (0.10 mole) of ethyl bromide is added and the heating continued for an additional 3 hours. The solvent and residual ethyl bromide are removed at reduced pressure (water aspirator) while the flask is heated in a water bath kept at about 60° (Note 1). The oily residue is treated with about 300 ml. of absolute ether, and on scratching crystallization is induced. The product is collected on a Buchner funnel, washed with two 50-ml. portions of anhydrous ether, and dried in a vacuum desiccator. The yield of colorless 2-methylbenzylethyldimethylammonium bromide is 47.5-49.0 g. (92-95%) (Note 2). It is hygroscopic and should therefore not be exposed to moist air. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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