Methyl, TV-

The structure of the intermediate obtained from 3-phenyl-5-amino-l,2,4-thiadi-azole (Goerdeler and Deselaers, 1958) was elucidated by UV- and IR-spectroscopy. The results are consistent with the nitrosoamine structure 3.18. Its UV spectrum (Fig. 3.4) is very similar to that of the A-methyl-TV-nitroso compound 3.19, but different from that of the isomeric compound 3.20 with a methyl group in the 4-position (Goerdeler and Deselaers, 1958). The spectrum of this 4-methyl derivative is expected to be similar to that of the nitrosoamine structure 3.21, which is obviously not present, at least not in detectable tautomeric equilibrium concentration. 

In the reaction of A-methylaniline, ethyl orthoformate, and Meldrum s acid (421) in the presence of p-toluenesulfonic acid monohydrate at 100°C for 2 hr, then for 3 days at ambient temperature, (jV-methyl-TV-phenylamino)methylenemalonate (443) was obtained in 41% yield (69BRP1147759). 

In analogy to proline dipeptides, A1-unprotected 2-carbonylpyrazolidine amino acid dipeptide esters 37 on storage at ambient temperature are prone to conversion into the related triazines 38 that correspond to the aza analogues of piperazine-2,5-diones (Scheme 5). 160 161 An additional side reaction is reported for the 2-azaproline peptides 161 which leads to formation of the cyclic imide 40 from methyl TV -lbenzyloxycarbonylj -carbonylpyra-zolidine glycinate (39) upon treatment with methanolic ammonia (Scheme 6). 

Polyelectrolytes Polyether block copolymers Polyvinylamides dimethlyaminoethyl methacrylate For example, poly(7V-methyl-TV-vinyl acetamide) CSM (Sloan, 1995a,b) CSM (Sloan, 1995a,b) CSM (Sloan, 1995a,b) ... 

Dihydroxy-4//-pyrido[l,2-a]pyrimidin-4-one 334 was obtained, when dibenzyloxy derivatives 333 were hydrogenated in dimethylform-amide in the presence of yV-methyl-TV-trimethylsilyl trifluoroacetamide. Dihydroxypyrido[l, 2-a]pyrimidin-4-one334 was then reacted, without isolation, with (Z)-2-amino-a-[(2-diphenylmethoxy)-l, l-dimethyl-2-oxoe-... 

The treatment of 4-oxo-4Z/-pyrido[ 1,2-a]pyrimidine-3-carboxylic acid 429 with phosphorus pentachloride in dichloromethane at 0°C gave acid chloride 430, which reacted with amine 431 in tetrahydrofuran in the presence of /V-methyl-TV-trimethylsilyl trifluoroacetamide at room temperature overnight to give /-substituted 3-carboxamide 432 (88USP4777252). After catalytic debenzylation, the 3-substituent of 4//-pyrido[l, 2-a]py-rimidin-4-one 433 was involved in different reactions to give antibacterial derivative 434 (see Scheme 25). 

Isopropyl - 1 - methyl - 5 - [A - methyl - TV - (a - methylphen-ethyl)aminomethyl]-2-phenyl-4-pyrazolin-3-one C24H3iN30 = 377.5... 

Reaction of resin bound S-methyl-TV-acylisothioureas 212 with hydrazines followed by acidic cleavage yielded 3-amino-1,2,4-triazoles 213 under mild conditions <03TL7841>. 3,4,5-... 

Wolfe et al. (1978) have developed structure-activity relationships for the hydrolysis of a number of TV-substituted and TV,TV-disubstituted carbamates. An excellent correlation was found between the second-order alkaline hydrolysis rate constant (kb) for the carbamates and the pKa of the alcohol formed upon hydrolysis. The linear free energy relationships for the TV-phenyl and TV-methyl-TV-phenyl carbamates are illustrated in Figure 2.10. These data indicate that only the TV-phenyl carbamates will hydrolyze under environmental conditions. The half-life for the hydrolysis of these chemicals will be less than 6 months at pH 8 at 25°C. 

TV-Methyl-TV-trimethylsilylacetamide [7449-74-3] M 145.3, b 48-49"/llmm, 84 /13mm, 105-107 /35mm (solid at room temperature), d 4 0.90, Ud 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in C6Hg, then redistil otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4IV 4011.]... 

The formation of nitrones by reaction of aldehydes and ketones with iV-methyl-tV,0-bis(trimethylsilyl)hydroxylamine is accelerated when TMSOTf is used as a catalyst the acceleration is particularly pronounced when the carbonyl group is under a strong electronic influence (eq 20). ... 

Photoconductive resins 2-Methyl-N-vinyl indole, 3-methyl-TV-vinyl indole United States 3,554,741 1971 IBM... 

Hydrazino-7-nitrobenzofurazan, H-00084 Mansylhydrazine, in M-00222 (7-Methoxy-2-oxo-2//-l-benzopyran-4-yl) methyl-TV, 7V -bis( 1 -methylethyl) carbamimidate, M-00099... 

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