Methyl radical Methylamine

Nitrosomethane (1) is known to be less stable than its isomer formaldoxime 2 and original attempts to isolate this species failed owing to its facile isomerization to the oxime 2. Already Bamberger and Seligman considered in 1903 that it would be difficult to isolate nitrosomethane after oxidation of methylamine due to its rapid isomerization to 2. Hence, 2 is always present in the synthesis of the nitrosomethane. Nitrosomethane is produced in the pyrolysis or photolysis of tcrf-butyl nitrite and by the reaction of methyl radicals with nitric oxide. Early results were confusing since the final product obtained is dimeric nitrosomethane. It was first isolated in 1948 by Coe and Doumani from the photolysis of gaseous ferf-butyl nitrite according to the overall reaction shown in equation 2. 

Attempts have been made to mimic the above reactions under nonenzymatic conditions. Methylcobalamin methylates homocysteine, but the reaction is a free radical process . Also, MeH4THF does not methylate cobaloxime(I) or Bj2s. AI-Methylamines are also unreactive toward Co(I) species. Tetraalkylammonium compounds alkylate Co(I) nucleophiles to form alkylcobalt compounds" it is possible that MeH4THF is protonated by the enzyme and Ais methylates the cobalamin. Methylation in low yield of cobalamin(I) by MeH4THF at low pH has been disputed. ... 

The salt is sometimes called methylamine hydrochloride, and its formula is written CH3NH2.HCI. The replacement of hydrogen in ammonium hydroxide by positive alkyl groups yields compounds which react with water and form bases much stronger than ammonium hydroxide. The accumulation of positive radicals in the quarternary ammonium bases results in the production of marked basic properties in these compounds. Tetra-methyl-ammonium hydroxide shows about as strong basic properties as potassium hydroxide. 

A novel series of water-soluble amphoteric cyclocopolymers containing the pH-responsive hydrophobic monomer, iV,iV-diallyl-iV-methylamine [2424-01-3], and the sulfobetaine monomer, 3-(iVA -diallyl-iV-methylammonio)-propanesulfonate, have been prepared in 0.5 M NaCl aqueous solution (pH 4.0), using 2-hydroxy-l-[4-(hydroxyethoxy)phenyl]-2-methyl-l-propanone (Ir-gacure 2959) as the free-radical photoinitiator (165). Equilibrium dialysis experiments demonstrated that they could be utilized to control the sequestration of organic foulants and thus have potential application as polymeric surfactants in micellar-enhanced ultrafiltration processes for water purification. 

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