Methyl quinoxaline-2-carboxylate

HydroxymethylquinoxalLne (and a corresponding ester, methyl 2-quinoxaline-carboxylate) have been found to induce significant single-strand scission of DNA by additive-free irradiation at 365... [Pg.219]

Methyl 6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydro-2-quinoxalinecarboxylate (1, R = Me) gave 6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydro-2-quinoxaline-carboxylic acid (1, R = H) (IM NaOH, 20°C, 79 min 79%). ... [Pg.318]

Ethyl 3-methyl-2-quinoxalinecarboxylate (60, R = Et) gave 2-diethylaminoethyl 3-methyl-2-quinixalinecarboxylate (60, R = CH2CH2NEt2) (neat HOCH2 CH2NEt2, reflux, 4 h 21%) or 2-morpholinoethyl 3-methyl-2-quinoxaline-carboxylate [60, R = CH2CH2N(CH2CH2)20] [neat HOCH2CH2N(CH2 CH2)20, reflux, 4 h 66%].475... [Pg.328]

Duque-Montano BE, Gomez-Caro LC, Sanchez-Sanchez M, Monge A, Hemandez-Baltazar E, Rivera G, Torres-Angeles O (2013) S3mthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-W-oxide against Entamoeba histolytica. Bioorg Med Chem 21 4550-4558. doi 10.1016/j.bmc.2013.05.036... [Pg.111]

Ethyl 1 -substituted 7-hydroxy-5-oxo-1,2,3,5-tetrahydropyrido[ 1,2,3-<7e] quinoxaline-6-carboxylates were reacted with A- [3,5-bis(trifluoromethyl)-phenyl]methyl methylamine to yield carboxamides (01MIP12). [Pg.315]

Dimethylquinoxaline (147) gave 2-ethoxycarbonyl-2-hydroxy -methyl-2,3-dihydro-[l/ ]-pyrrolo[l,2-u]quinoxalin-10-ium bromide (148) (BrCH2CO-C02Et, AcEt, reflux, 3h, then 20°C, 12 h 72%) and thence successively ethyl 4-methylpyrrolo[l,2-fl]quinoxaline-2-carboxylate (149) (EtONa, EtOH, 20°C, 4h 93% note oxidation by loss of H2O), the uncharacterized quaternary salt (150) (as the first step but 6h 50%), and diethyl dipyr-rolo[l,2-fl 2, l -c]quinoxaline-2,ll-dicarboxylate (151) (KOH, H2O, reflux, 1 h 56%). ° " - ... [Pg.119]

Methyl-l-phenyl-2(17/)-quinoxalinone (226) and methyl methacrylate (227) gave the photoadduct, methyl l,2a-dimethyl-3-oxo-4-phenyl-2,2a,3,4-tetra-hydro-l//-azeto[l,2-fl]quinoxaline-l-carboxylate (228) as a separable mixture of two stereoisomers (CH2CI2, MeOH, hv, N2, <15 h 40% each) analogs likewise. " ... [Pg.225]

Chloro-2-(Af-methylhydrazino)quinoxaline 4-oxide (295) gave ethyl 7-chloro-1 -methyl- //-[ 1,3,4]oxadiazmo[5,6-Z7]qumoxaline-3-carboxylate (296) (Et02-CCOCl, pyridine, CHCI3, 5°C —> reflux, 2 h 81% mechanism discussed). ... [Pg.240]

The same substrate (25) aud ethyl 2-chloroacetoacetate gave an analogous product, ethyl 3-hydroxy-3-methyl-3,4-dihydro-2//-1,4-thiazino[2,3-h]qui-noxahne-2-carboxylate (27) (KOH, EtOH, 20°C, 3 h 58%), which underwent dehydration to ethyl 3-methyl-2H-1,4-thiazino[2,3-h]quinoxaline-2-carboxy-late (28) (HCl gas, EtOH, 20°C, 15 h 60% analogs likewise). ... [Pg.245]

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