6-methyl-2-pyridinolates

Ru(6-methyl-2-pyridinolate)2(PPh3)2, 2,795 4, 466 RuC48H44C12P4 RuCl2(PHPh2)4,4, 378 RuC4sH44N03P 2... 

Reaction of [Ru2(OCOMe)4Cl] with sodium 6-methyl-2-pyridinolate [Na(mph)] at ambient temperature gives an 8% yield of [Ru2(mhp)4]-CH2Cl2 (409) (r(Ru—Ru) = 2.238(1)A). Magnetic (/feff = 2.9 BM/molecule) and PE spectral measurements suggest a groimd state elec-... 

C H, N02 13287-64-4) see Pyridinol carbamate 6-methyl-2-pyridinemethanol acetate (ester) 1-oxide (GjHjiNOj) sec Pyridinol carbamate... 

Elming, N. Clauson-Kaas, N. 6-Methyl-3-pyridinol from 2-hydroxymethyl-5-aminomethyl-furan, Acta Chem. Scand., 1956, 10, 1603-1605. 

Scheme 19.—Mechanism for Formation of 2-Acetylpyrrole and 2-Methyl-3-pyridinol.

Pyridinol carbamate has been used as an anri-inflammatory/anti-arteriosderotic. This compound 2,6-pyridinedimethanol-bis-(N-methyl carbamate) is also known as Anginin. See rhe formula below1. 

The fragmentation of 2-acylpyrroles (6) and 3-pyridinols (7) on electron impact (El) has been elucidated and is shown for L -7 in Figure 7. The two numbers under each ion are the m/z values expected with the label at the alternative positions, the latter number within parantheses corresponding to labelled methyl carbon. Where the two m/z values differed, the peak at the first one always predominated in the El mass spectra of the labelled (J-7 obtained on GC/MS analysis of Extracts 1 and 3. This was in complete accordance with the 1 5C-NMR spectrometric results, but for several reasons the mass spectrometric results were less accurate and did not exclude up to 15 % of the label in the respective methyl groups. Most important, the spectra showed clusters of peaks at consecutive m/z values, including those of interest. The content was calculated by means of a computer program based on the somewhat doubtful assumption that ions in the same cluster differed only in hydrogen content and/or isotopic composition. 

Pyridines and pyrroles can be formed in different pathways by Mail-lard reaction. The formation of 5-methyl pyrrole aldehyde and 6-methyl-3-pyridinole has been observed by Nyhammar et al (17) by the reaction of isotope labelled 3-deoxyosone with glycine. The 3-deoxy-hexosone represents an -dicarbonyl compound and in this way the Strecker degradation occurs. Another pathway is the reaction of fu-rans with ammonia. Under roast conditions, we have obtained primarily the corresponding pyrrole, whereas we found the corresponding py-... 

It is not requisite that the anion eliminated in the step 19 to 20 be a hydroxyl ion, because acid hydrolysis of 5-amino-5-deoxy-l,2-0-isopropylidene - 3 - O - (methylsulfonyl )-a- D -xylofuranose likewise yields 3-pyridinol (21). On subjection to acid hydrolytic conditions which remove the 2V-acetyl group, such N-acetyl derivatives as 5-acetamido-5-deoxy-a-D-xylopyranose (see p. 167) are immediately transformed, through 17, into 3-pyridinol (21). Furthermore, acid hydrolysis of methyl 5-acetamido-5-deoxy-2,3,4-tri-0-methyl-a-D-... 

The reaction of 5-amino-5-deoxy-l,2-0-isopropylidene-a-D-xylo-furanose (15) with methanolic hydrogen chloride (0.5 %), under careful exclusion of moisture, results in a mixture of the anomers of methyl 5-amino-5-deoxy-D-xylofuranoside, from which the /8-D anomer crystallizes. The five-membered ring-structure was proved by the results of periodate oxidation and by the infrared spectrum of the tetraacetate, which shows a band for NH. A methyl pyranoside was not found, and 3-pyridinol (21) was formed only in traces. A spontaneous ring-enlargement, such as is observed under similar conditions with 1,2-O-isopropylidene-5-thio-a-D-xylofuranose (see p. 208), is not possible in this instance. Stabilization as the methyl fiiranoside is, apparently, so rapid that the secondary reaction (leading to the pyranose form) does not occur. If water (several percent) is added to the reaction mixture, glycoside formation is hindered, and a large proportion of 3-pyridinol is formed. ... 

C4H10S methyl propyl sulfide 3877-15-4 -112 98 1.1274 2 4261 C5H4BrNO 2-bromo-3-pyridinol 6602-32-0 25.00 1.7203 2... 

In addition to the above-described alkyl phosphates, a few less common metabolites can be mentioned, e.g. 3,5,6-trichloro-2-pyridinol (TCP). TCP is a major product of esterase cleavage of the OPi chlorpyrifos and chlopyrifos-methyl." ° Urinary TCP, like other... 

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