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Methyl parahydroxybenzoate oral liquids

Methyl parahydroxybenzoate (MOB or methylparaben) is most widely used in oral liquids. As an ester it is stable between pH 3 and 6. Outside these pH liinits methylparaben will hydrolyse, which amounts for example to 25 % in 12 months in an oral solution with pH 7.0-7.5 (prednisolone oral solution, see Table 23.23) at room temperature. [Pg.88]

For the preservation of oral liquids and dermatological preparations at pH <5, sorbic acid or methyl parahydroxybenzoate is used, at pH 5-7 methyl parahydroxybenzoate, and at pH >7-8.5 methyl parahydroxybenzoate, even though its preservative effect is weak. It is therefore advised to reduce the pH or pay extra attention to the prevention of contamination. [Pg.447]

Syrups are a very commonly used form of sugars. They contain approximately 45-65 % of sugar, water and a preservative. Sometimes a flavouring is added. The preservative is most often methyl parahydroxybenzoate 0.1-0.15 %. Syrups can be very useful for improving the taste of oral liquid preparations and sometimes they can be used to stabilise a solubilisate of oil and polysorbate, e.g. in a vitamin A micellar solution (Table 23.12). [Pg.480]

Sorbic acid is mainly used in cutaneous preparations and in oral liquid preparations. Because of the favourable oil-water partition coefficient it is suitable for formulating hydrophilic creams, emulsions and micellar solutions for oral use. For this reason it is preferred to methyl parahydroxybenzoate in these preparations. [Pg.494]


See other pages where Methyl parahydroxybenzoate oral liquids is mentioned: [Pg.64]    [Pg.92]    [Pg.94]   
See also in sourсe #XX -- [ Pg.88 ]




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Methyl parahydroxybenzoate

Oral liquids

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