Methyl 2-mercaptoacetate

Chloro-3-cinnolinecarbonitrile (76) with methyl 2-mercaptoacetate gave methyl 3-aminothieno[3,2-c]cinnoline-2-carboxylate (75) (Na2C03, EtOH, reflux, 4h 90%) or with methylhydrazine gave 1-methyl-lH-pyrazolo [4,3-c]cinnolin-3-amine (77) (MeHNNH2, EtOH, reflux, 2h 53% analogs... 

CAS 2365-48-2 EINECS/ELINCS 219-121-7 Synonyms Acetic acid, mercapto-, methyl ester Mercaptoacetic acid methyl ester Methylmercaptoacetate Methyl-2-mercaptoacetate Thioglycolic acid, methyl ester... 

Alternate Names methyl 2-mercaptoacetate, thioglycolic acid methyl ester, mercaptoacetic acid methyl ester, MTG. 

Methyl (aUylthio)acetate, CH,—CHCH2SCH2COOCH3 (1). Mol. wt. 146,21. The reagent is prepared from allyl bromide and methyl mercaptoacetate (83% yield). 

A number of densely substituted 3-aminothiophene derivatives, including several fused systems, have been obtained by cyclization reactions of suitable acrylonitriles or similar precursors with ethyl mercaptopyruvate in the presence of a base, as illustrated by the conversion of the pyridine-1-oxide 4 into the pyridothiophene 5 <05JHC661>. Similar annulations involving 2-amino-4,6-dichloropyrimidine-5-carboxaldehyde and methyl mercaptoacetate leading to thieno[2,3-t/]pyrimidine derivatives have also been reported <05JHC1305>. 

It has been demonstrated that vinamidinium salts, which have previously been used for the construction of pyrroles, may also serve as useful starting materials for the synthesis of 2,4-disubstituted thiophenes. Thus, heating of the salts 6 with methyl mercaptoacetate 7 in DMF afforded useful yields of the thiophenes 8 <05TL1319>. 

Methyl mercaptoacetate C3HP3S CH30C(=0)C(H3)SH LB02 411 8 state 0+... 

Methyl mercaptoacetate added in small portions with shaking or stirring to a 10% soln. of N-isothiocyanatodiisopropylamine in pentane methoxycarbonyl-methyl N,N-diisopropyldithiocarbazate, Y 76%. F. e. s. U. Anthoni, C. Larsen, and P. H. Nielsen, Acta Chem. Scand. 25, 3385 (1969). 

S - Methyltliioglycollic Acid (Methyl -mercaptoacetic acid, methyl sulphide carboxylic acid)... 

Benzyl mercaptan added at —80° during 1 hr. to a soln. of thiocyanogen prepared from lead thiocyanate and bromine in ether, stirred 0.5 hr., the resulting crude benzylsulfenyl thiocyanate (Y 94.1%) dissolved in ether, immediately added at —10° to methyl mercaptoacetate in dry ether, and stirred 2.5 hrs. 

Trifluoromethylpyranopyrazole 121 reacted at C(6) atom with excess of methyl mercaptoacetate in the presence of triethylamine to form a derivative 122 of trifluo-romethyl thiophene bonded with a pyrazole fragment. The reaction took place via pyran ring opening and intramolecular aldol-type condensation [71],... 

Methyl magnesium bromide Methylmagneslum chloride Methylmalonic acid Methyl mercaptoacetate Methyl 3-mercaptopropanoate Methylmercuricdicyanamide... 

On the other hand, 4-amino-5-carbethoxy-2-methylthiothiazole (260) was obtained by condensing methyl-N-cyanoiminodithiocarbamic esaer (259) with ethyl-a-mercaptoacetate (258) in foramidine in the presence of triethylamine (Scheme 133) (564). 

Elemental and inorganic compounds Manganese cyclopenta-dienyl tricarbonyl as Mn Manganese methyl-pentadienyl tricarbonyl Manganese tetroxide Man-made mineral fibre Marble, see Calcium carbonate Mercaptoacetic acid, see Thioglycolic acid Mequinol (INN)... 

Mixture of 62.82% dipropylene glycol, 21.18% mercaptoacetic acid, 6% n-hexanoic acid, 6% N-methyl morpholine, 2.18% p-cresyl isovalerate, 0.91% 2-naphthalenethiol, and 0.91% skatole. 

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