2-Methyl-l,4-naphthohydroquinone

Among the many phosphorus compounds selected by Mitchell and his collaborators may be mentioned tetrasodium 2-methyl l 4-naphthohydroquinone diphosphate (VTH). A concentration of 4 x 10 6 M of (VIII) produced a 50 per cent mitotic inhibition using chick fibroblasts in tissue culture. It is thought that the inhibition of the entry of cells into mitosis depends on the blockage of cellular synthetic processes involving phosphoryla-... 

The condensation of allylic alcohols with phenolic compounds in the presence of an acid catalyst yields allylphenols. This reaction was used 86 in a synthesis of vitamin K (LXXVa) by condensing phytol with 2-methyl-l,4-naphthohydroquinone in dioxane with oxalic or trichloroacetic acid as catalyst the hydroquinone first formed was oxidized to... 

BF3 Et20 is useful for the condensation of allylic alcohols with enols. A classic example is the reaction of phytol in dioxane with 2-methyl-l,4-naphthohydroquinone 1-monoacetate to form the dihydro monoacetate of vitamin Ki (Eq. 30), which can be easily oxidized to the quinone [57]. 

Methyl-l, 4-naphthohydroquinone Phosphorus oxychloride Sodium hydroxide... 

The hemolytic effect of menadione may be demonstrated also in vitro with red blood cells obtained from vitamin E-deficient rats (Rose and Gyorgy, 1960). This was first shown in vivo by Allison el al. (1956). The tetrasodium salt of the diphosphoric acid ester of 2-methyl-l, 4-naphthohydroquinone (Synkayvite ) was inactive in vitro but produced hemolysis after pretreatment with phosphatase (Rose and Gyorgy, 1960). The natural vitamin Ki was inactive in vivo as well as in vitro. Vitamin E prevents the hemolysis by vitamin K derivatives. In agreement with Nitowsky and Marks, it is... 

Methyl-l, 4-naphthohydroquinone 2-Methyl-l, 4-naphthohydroquinone > 2-Methyl-l, 4-naphthohydroquinone 2-MethyI-l, 4-naphthohydroquinone +0.713 +0.095 +0.062 +0.022 100... 

Aq. NaOBr added at 20° to 2-methyl-l,4-naphthohydroquinone in aq.-alc. H2SO4, and stirred 5 min. 2-methyl-1,4-naphthoquinone. Y 93%. F. e., also with... 

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