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Methyl l- 5-Methylisoxazol-3-yloxyacetoxy Alkyl Methylphosphinates IIIJ

20 0-Methyl [l-(5-Methylisoxazol-3-yloxyacetoxy)Alkyl] Methylphosphinates IIIJ [Pg.421]

General procedure To a stirred solution of appropriate (9-methyl (1-hydroxy-alkyl)methylphosphinates M12 (0.005 mol) and triethylamine (0.0072 mol) in 5 mL of trichloromethane, (5-methyl-isoxazol-3-yl)oxyacetyl chloride M16 (0.006 mol) in 5 mL of trichloromethane was added dropwise below 0 °C. The mixture was stirred at room temperature for 4—6 h. Normal workup and purification by column chromatography on silica gel and elution with petroleum ether/acetone (5/1, v/v) gave the corresponding pure tide compound. IIIJ-l-IIIJ-8 could be obtained by this procedure in 23-55 % yields [32]. [Pg.421]

The structures, physicochemical data, and yields of IIU-l-IIU-8 are listed in Table 9.32. [Pg.422]




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5-Methylisoxazole

5-methylisoxazol

Alkyl methylphosphine

Alkyl-methyl

L- alkyl

Methylphosphine

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