Isocyanides methyl isocyanoacetate

Methylimidazole, 1495 Methyl iminioformate chloride, 0893 Methyl iodide, see Iodomethane, 0444 f Methyl isobutyrate, 1970 f Methyl isocyanate, 0758 Methyl isocyanide, 0756 Methyl isocyanoacetate, 1466... 

Wong and co-workers [22] also applied the methodology in the preparation of a library of neomycin B mimetics (Fig. 6). Two libraries were prepared by a multiple-component condensation of neamine derived aldehyde, f-butyl isocyanide or isocyanoacetic acid methyl ester, CBZ-N amino acids (xl3) and a glycine conjugated polyethylene glycol methyl ether. The products of the reaction were isolated by precipitation. 

Asymmetric aldol reactions of a-keto esters (R-CO-COOMe R = Me, iBu, Ph) with methyl isocyanoacetate or N,N-dimethyl-a-isocyanoacetamide in the presence of 1 mol% of a chiral ferrocenylphosphine-gold(I) catalyst proceed enantiose-lectively (up to 90% cc) to give the corresponding oxazolines, which can be converted into optically active j8-alkyl-j8-hydroxyaspartic acid derivatives [1197]. Dehydration of the intermediate formamide to the corresponding isocyanide is accomplished in 97% yield with phosphoryl chloride at room temperature within 2h. 

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