Methyl 2,4-dihydroxy-6-methylbenzoate

Syntheses of the trans-7,8-dihydrodiol derivatives of 7-and 8-methylbenzo(a)pyrene via Method I have also been reported (24-26). Conversion of the latter to trans-7,8-dihydroxy-anti-9,10-epoxy-8-methyl-7,8,9,10-tetrahydrobenzo(a)pyrene, has also been described (26). [Pg.44]

The dianion of pentane-2,4-dione (97) reacts as the nucleophile with the enolate of dimethyl malonate to give the labile (98), which cyclizes to methyl 2,4-dihydroxy-6-methylbenzoate (99) at pH 5 (Scheme 36). ° ... [Pg.821]

Several substituted dihydroxybenzoic acids have been examined by the yeast oedema and granuloma pellet test in rats , and anti-inflammatory activity appears to be restricted to the substituted 2,6-dihydroxy compounds. The presence of a halogen at Cg and Cj produces activity which is further increased when a methyl or benzyl group is also present at G4. 4-Benzyl-2,6-dihydroxybenzoic acid is also active, despite the absence of halogen at Cg or C5. The most potent compound of all is 3,5-dichloro-2,6-dihydroxy-4-methylbenzoic acid XIII). Whenever anti-inflammatory activity has been... [Pg.78]

Methyl 5-chloroorseIlinate, Methyl 2,4-dihydroxy-5-chloro-6-methylbenzoate... [Pg.430]

Methyl haematommate, Methyl 2,4-dihydroxy-3-formyl-6-methylbenzoate (Haematommsauremethylester, 2,4-Dihydroxy-3-formyl-6-methylbenzoesauremethylester)... [Pg.435]

Methyl 5-hydroxyeverninate, Methyl 2,5-dihydroxy-4-methoxy-6-methylbenzoate... [Pg.436]

Also obtained by decarboxylation of methyl 3-acetyl-2,4-dihydroxy-6-methylbenzoate,... [Pg.772]

Also obtained by reaction of boiling solution of 1 N sodium hydroxide on methyl 3,5-diacetyl-2,4-dihydroxy-6-methylbenzoate, decarbonylation and decarboxylation occurring simultaneously [2691],... [Pg.772]

Preparation by treatment of methyl 2,6-dihydroxy-4-methoxy-3-methylbenzoate with an isobutyric anhydride and isobutyric acid mixture in the presence of boron trifluoride for 5 h at r.t. (87%) [7255], (77%) [8171]. [Pg.2044]

By condensation of 2,4-dibenzyloxy-6-methylbenzoic acid and benzyl 4-benzyloxy-3-(2, 4 -dihydroxy-6 -methyl-benzoyloxy)-6-hydroxy-2-methylbenzoate with TFAA and subsequent debenzylation From 4-benzyloxy-2-hydroxy-6-/i-pentylbenzoic acid and olivetol with DCCD and subsequent debenzylation From 2-hydroxy-4-methoxy-6-n-propyl-benzoic acid and divarol with DCCD From 2-hydroxy-4-methoxy-6-n-propyl-henzoic acid and 3-methoxy-5-n-propylphenol with DCCD From 4-benzyloxy-2-hydroxy-6-n-pentyl-benzoic acid and 3-methoxy-5-n-propylphenol with DCCD and subsequent debenzylation... [Pg.316]

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