2-Methyl-benz indene

Ci H2 iNOS2 72730-71-3) see Tiquizium bromide [3S-(3a,3acx,9aa,9bp)]-l,2,3j3a,8,9,9a,9b"Octahydro-3-hy-droxy-3a-methyl-6-(3-oxobutyl)-7 f-benz[ ]inden-7-one benzoate... 

CYCLOPENTANONE ANNULATION VIA CYCLOPROPANONE DERIVATIVES (3a(3.9b)3)-1,2,3a,4,5,9b-HEXAHYDRO-9b-HYDROXY-3a-METHYL-3H-BENZ[ ]INDEN-3-ONE... 

Benz[e]indene, dimethyl-1/-/-Benz[e]indene, ethylmethyl-1/-/-Benz[e]indene, methyl-1/-/-Benz[/]indene... 

The conversions of 144 - 145 and 146 -> 147 involve carbene insertion into a methyl and phenyl group, respectively. In the o-tolyl anhydride 162 both options are possible, but in fact its pyrolysis gave only products derived from interaction with adjacent methyl group. The products were fluorene 168 (49%) and the two benz[ ]indenes 169 and 170 (11% each). The initial intermediate is aryne 163, possibly the source of fluorene as shown, though... 

By reversing the reaction sequence, it was possible to invert the configuration of the hexahydro-l//-benz[/]indene product. Carbopalladation of the acetylenic substrate under the same conditions used above but in l-methyl-2-pyrrolidinone as the solvent gave rise to 46. Hydrogenation of 47 over Lindlar s catalyst afforded the cis isomer 48 of hexahydro-l//-benz[/]indene in quantitative yield. ... 

Spectator ligands. In such a way, titanium complexes with 2-phenyl-cyclopenta[I] phenanthrene [14] (II),2-methyl-benz[e]indene [15] (I), or 1,2,3,4,5,6,7,8-octa-hydrofluorene [16] (III) are important catalysts for styrene polymerization (Scheme 6.1). 

Methyl and Ethyl, 504 9-Fluorenylmethyl, 506 9-(2-Sulfo)fluorenylmethyl, 507 9-(2,7-Dibromo)fluorenylmethyl, 507 17-Tetrabenzo[a,c,gf,/]fluorenylmethyl, 508 2-Chloro-3-indenylmethyl, 508 Benz[f]inden-3-ylmethyl, 508... 

The research team of D.F. Covey developed a synthetic route to convert 5p-methyl-3-ketosteroids into 7(S)-methyl substituted analogues of neuroactive benz[e]indenes. The synthesis began with 19-nortestosterone, in which the a,p-unsaturated cyclic ketone moiety was degraded to afford a tricyclic aldehyde. This aldehyde was unstable and could not be stored. For this reason it was immediately subjected to the Tsuji-Wllkinson decarbonylation to afford the decarbonylated product in high yield. 

Zeng, C.-m., Han, M., Covey, D. F. Neurosteroid Analogues. 7. A Synthetic Route for the Conversion of 5P-Methyl-3-ketosteroids into 7(S)-Methyl-Substituted Analogues of Neuroactive Benz[e]indenes. J. Org. Chem. 2000, 65, 2264-2266. 

The transformation of 14 into 7-methoxy-fra 5-3a,9b-dimethyl-l,3,3a,4,5,9b-hexahydro-2/f-benz[e]inden-2-one (15) illustrates the use of the sequence consisting of cyclopropanation, followed by dissolving metal reduction, for the introduction of angular methyl groups into structures containing condensed alicyclic rings. 

Oxandrolone, 17-Hydroxy-l 7-methyl-2-oxaan-drostan-3-one dodecahydro -3 -hydroxy -6 -(hydroxymeth yl)-3,3a,6-trimethyl -]H-benz[e]indene-7 -acetic acid 6-lactone Anavar Lonavar Provitar Vasorome. Ci9HjqOj mol wt 306.43. C 74.47%, H 9.87%, O 15.66%. Prepn PappO, Jnng, Tetrahedron Letters 1962, 365 Pappo, U.S. pat. 3,128,283 (1964 to Searle). 

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