3- MethyI-l-butanol

S,3R)-4-Dimethy]amino-3-methyI-l,2-diphenyl-2-butanol (7) is a commercially available compound which is produced on an industrial scale because of the analgesic effects of its esters6. It has also been called dextrocarbinol base, or Darvon alcohol, or Chirald. It can be prepared from propiophenone by Mannich reaction with subsequent addition of benzylmagnesium chloride6. Resolution is achieved with ( — )-10-camphorsulfonic acid. Applications include enantioselective reduction of ketones by complex hydrides modified with this amino alcohol8,9 and catalysis in the addition of zinc alkyls to carbonyl compounds (Section D. 1.3.1.4.). 

Oxy-3-metboxy-l-batyI-benzol 6 II898. l-[2-Metboxy-plienyl]-bntanol-(3) 6 II898. l-f3-Hetbozy-pbenyl]-butanol-(l) 6, 942. l-[4-Hetb[Pg.2197]

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