Methsuximide anticonvulsant

Succinimides. Ethosuximide [77-67-8] C2H22NO2 (41) and the related succinknide, methsuximide [77-41-8] C22H23NO2 (42) are used in absence seizure treatment. Like the other anticonvulsants discussed, the mechanism of action of the succinirnides is unclear. Effects on T-type calcium channels and -ATPase activity have been reported (20). Ethosuximide has significant CNS and gastrointestinal (GI) side effect HabiUties (13). 

Methotrimeprazine as analgesic, 1, 168 Methoxalen applications, 4, 707 Methsuximide as anticonvulsant, 1, 166 Methyclothi azide as diuretic, 1, 174... 

Use of acetophenone rather than benzaldehyde in the Knoevnagel condensation reaction affords the unsaturated ester, 13. Elaboration of this to the succinimide by a scheme analogous to that above leads to the anticonvulsant agent methsuximide (14)... 

Another anticonvulsant of somewhat similar structure is Methsuximide, 1,3-dimethyl-3-phenyl-2,5-pyrrol-indinedione, a substance freely soluble in alcohol, the enantiomers of which have also been separated on a cellulose based chiral stationary phase. The structure of Methsuximide is as follows. 

The Separation of the Enantiomers of the Anticonvulsants Ethotoin and Methsuximide Courtesy of CHIRAL Technologies Inc. 

The chemicals that induce hepatic porphyria in man, animals, or chick embryo cells in culture consist of a wide variety of organic compounds that differ in physiologic activity. They include, for example, the central nervous depressants such as the barbiturates, sulfonme-thanes, and glutethimides the anticonvulsant methsuximide the central nervous stimulant bemegride the fungicides griseofulvin and hexachlorobenzene some chlorinated insecticides and the isoprenoid terpenes and steroids [2,10,11,24,25]. 

Multiple ion monitoring is a powerful method for the simultaneous quantitation of drugs and their metabolites and two approaches are available. The first relies on quantitation using an unlabelled standard. A representative application (15) is that of the determination of the plasma level of methsuximide (j6), an anticonvulsant, and its metabolite N-desmethylmethsuximide (7 )... 

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