4-methoxyphenyl 2-naphthyl

Polyphosphoric acid is a commonly used catalyst for this reaction however, in some cases a mixture of hydrogen bromide/acetic acid gives better results. Acylation of the S-phenyl-, V-(4-tolyl)- or S-(l-naphthyl)-substituted thiobenzenepyruvic acids 3a-c affords the corresponding dibenzo[A,/]thiepins in satisfactory yields, while reaction of the S-(4-methoxyphenyl) or S-(2-naphthyl) derivatives fails to provide any thiepin.60 The intramolecular Friedel-Crafts acylation of 2-(arylsulfanyl)benzeneacetic acids also yields the corrresponding dibenzothiepins in this case the use of hydrogen fluoride sometimes results in purer products.38 The applicability of this method is restricted to the synthesis of stable bisannulated thiepins. 

Cj]HyBrMgO 38046-82-1) see Naproxen (5)-2-(5-bromo-6-methoxy-2-naphthyl)propanoic acid (Ci4Hi BrO 84236-26-0) see Naproxen bromo(3-methoxyphenyl)magnesium (C7H7BrMgO 36282-40-3) see Tramadol (/f)-2-bromo-A -[2-(4-methoxyphenyl)-l-methylethyl]-acetamide... 

Methoxyphenyl)-3 -methyltriazene, 3000 l-(2-Naphthyl)-3-(5-tetrazolyl)triazene, 3394 /V-Phenylazopiperidine, 3407... 

Magnetic field effects have been used to study the photo-Eries rearrangement of 4-methoxyphenyl acetate [49] and 1-naphthyl acetate [50], These effects can be subdivided into internal and external. 

In model compounds, the aliphatic side chains on aromatic nuclei transalkylate without rearrangement s ll However, the reaction of aliphatic bridges is more complicated. For example, transalkylation of l-(4-methoxyphenyl)-3-(2-naphthyl)... 

Conducted in toluene. BHA = 2,6-di-ter -butyl-4-methoxyphenyl Naph = naphthyl Cy = cyclohexyl Ar = 2,6-diisopropylphenyl ent = enantio. Molar equivalents to the amounts of organolithium. 

Dihydro-4//-l,3-thiazines 231 are conveniently prepared by the iodocyclization of A -homoallyl thioamides 230 in the presence of triethylamine (Scheme 28) <2004CL508>. The selectivity of the reaction was dependent on the groups attached to the thioamide, and high diastereoselectivities are achieved with the 1-naphthyl or the 2-methoxyphenyl groups giving the major product 233 with the aryl group in the equatorial position rather than 234. Treatment of thiazines 231 with pyrrolidine resulted in the formation of 6-alkylidene-5,6-dihydro-4//-l,3-thiazines 232. 

This procedure illustrates the best way to prepare aryl isocyanides. It is quite general, having been used by Ugi and Meyr e to make the following isocyanides from the corresponding form-amides phenyl (56%), />-tolyl (66%), 2,6-dimethylphenyl (88%), mesityl (80%), o-chlorophenyl (43%), -chlorophenyl (54%), 2-chloro-6-methylphenyl (87%), -methoxyphenyl (64%), p-di-ethylaminophenyl (75%), -nitrophenyl (41%), and 2-naphthyl (50%). Aliphatic isonitriles are generally best prepared by a simpler procedure involving the action of phosphorus oxychloride on an N-alkylformamide in the presence of pyridine.7... 

Another structurally related series is the 2-ary 1-1,8-naphthyridin-4-ones (37 to 48, see Table 6.7), which contain a second nitrogen in the aromatic A ring. Compounds with meta-substituted phenyls (methoxy-, chloro-, or fluoro-) or a-naphthyl groups at the C-2 position showed potent cytotoxicity in the NCI 60 human tumor cell line panel with GI50 values in the low micromolar to nanomolar range (Tables 6.7 and 6.8).51 The tumor cell line selectivity varies with the various substituents. 2-(3 -Methoxyphenyl)-naphthyridinone (37) was significantly more cytotoxic in several cancer cell lines than the corresponding 2-(3 -meth-oxyphenyl)-quinolone (36). Both compound classes were potent inhibitors of tubulin polymerization the 2-ary 1-1,8-naphthyridin-4-ones had activity nearly comparable with those... 

Ethyl, methyl > m-tolyl, phenyl >/>-tolyl, p-ethoxyphenyl, p-methoxy-phenyl, o-tolyl, o-ethoxyphenyl, o-methoxyphenyl > cyclohexyl, mesityl, 1-naphthyl. The reaction is catalyzed by metal salts such as aluminum chloride. 

Nl - KETONE, 3 4-DIHYORO-2-(p-METHOXYPHENYL)-l-NAPHTHYL-p-C2-(l-PYRROLIDINYl)E-THOXY)PHENYL METHANESULFONATE... 

Detailed proton NMR spectroscopic data on a variety of fused and spiro thietane and thiete derivatives was tabulated in the corresponding sections of CHEC(1984) and CHEC-II(1996). Therefore, only limited, newer information is presented here. A series of iV-(4-methoxyphenyl), iV-(l -naphthyl), iV-benzyl, and iV-(4-nitrophenyl)-,/V-(thietan-3-yl)benzene- or methanesulfonamides 13 as well as the analogous iV-aryl-iV-(thietan-3-yl)-2-nitroben-zenesulfonamides 14, 3-arylaminothietanes 15, iV-(4-aryl)-iV-(l-oxothietan-3-yl)-2-nitrobenzenesulfonamides 16, iV-(l,l-dioxothietan-3-yl)-Ar-(aryl)-2-nitrobenzenesulfonamides 17, 3-(4-arylamino)thietane 1,1-dioxides 18, and iV-(4-aryl)-iV-(thietan-2-yl)benzamides 19 were identified on the basis of their H NMR spectra <2005RJ01023>. 

Bis[4-methylphenyl] ditellurium, bis[4-methoxyphenyl] ditellurium, and bis[4-ethoxy-phenyl] ditellurium, but not diphenyl or bis[2-naphthyl] ditcllurium, reacted with 2-(phenyliodonio)-benzoates producing compounds with two vicinal aryltelluro substituents in the aromatic ring. The reactions are postulated to proceed via the thermally generated singlet benzyne and concerted addition of the diaryl ditellurium compounds. 

Methoxyphcnyl tellurium trichloride and 2-naphthyl tellurium trichloride reacted with acetophenone in a refluxing mixture of carbon tetrachloride/acetic acid (20 1) to give benzoylmethyl 4-methoxyphenyl tellurium dichloride (m.p. 137°, 96% yield) and benzoylmethyl 2-naphthyl tellurium dichloride (yield 91% m.p. 148°) after 12h2. 

---