2-Methoxycarbonyl-5,6,7,8-tetrahydro

Pyrrolidino- bzw. 3-Piperidino-acrylsaure-ester cyclisieren mit Phenyldiazonium-tetrafluoro-borat unter Einbau eines N-Atoms aus dem Diazonium-Salz zu 2-Methoxy carbonyl-6,7-di-hydro-5 H-yrrolo[l, 2-d imidazol ) (40%) bzw. 2-Methoxycarbonyl-5,6,7,8-tetrahydro-[Pg.59]

Athoxycarbonyl-athyl)- 340 2-(2-Athoxycarbonyl-athyl)-tetrahydro- 340 2-Athoxy-4-methoxycarbonyl-tetrahydro- 639 2-Athyl- 333... 

Azocin-2( 1H )-one, hexahydro- 1-phenyl-photochemical rearrangement, 7, 656 Azodn-2( 1H )-one, 1,2,7,8-tetrahydro-synthesis, 7, 662 Azocin-5-one IR spectra, 7, 16 transannular interactions, 7, 14 Azocin-5-one, l-(2,4-dimethylphenyl)-IR spectrum, 7, 657 Azocin-5-one, methoxycarbonyl-synthesis, 7, 657 Azocin-5-one, 1-methyl-IR spectrum, 7, 657 synthesis, 7, 657 Azodn-5-one, 1-p-tolyl-IR spectrum, 7, 657 Azocinones... 

Mit Oxalsaure wird 5,6-Dihydroxy-(j>yrazino[2,3-c furazan 290 (30%) und mit Butindisaure-dimethylester 6- ( Methoxycarbonyl-methylen)-5-oxo-4,5,6,7-tetrahydro-(pyrazino 2,3-c fura-zan 2S5 (74%) erhalten ... 

Analog erhalt man Brom- und Alkoxycarbonyl-substituierte Produkte wie z.B. 1-( 2-Brom-4-methoxycarbonyl-benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isochinolin (61%). Ein Beispiel aus der Steroid-Chemie ist die Herstellung von / 7fi-Dimelhylamino-3-hydroxy-17a-methyl-5-androsten aus einem Iminium-Salz2 ... 

The protoberberine alkaloid, xylopinine, has been synthesized in an optically active form by Kametani et al.22 ). A key reaction in this synthesis was the photochemical cyclization of the optically active amino acid derivative 1,2,3,4-tetrahydro-6,7-dimethoxy-3-methoxycarbonyl-1 -methylene-2-veratroylisoquinoline with 1,3... 

Magnesium, 3-[(17S)-7-formyl-8-ethyl-132-methoxycarbonyl-2,12,18t-trimethyl-13 -oxo-S-vinyl-lB1,13 2,17,18-tetrahydro-cyclopenta[at] porphyrin-17r-yl]-propionato-[(7R,llR)-trans-phytylester]... 

Methoxy-7-methoxycarbonyl-1,2,3,4-tetrahydronaphthalene 2-Naphthalene-carboxylic acid, 5,6,7,8-tetrahydro-3-methoxy-, methyl ester (78112-34-2), 65, 98 Methyl acrylate (96-33-3), 66, 54, 59 dimerization by Pd(II), 66, 52 Methylamine, N-benzylidene-, 65, 140 METHYL 4-0-BENZOYL-6-BROMO-6-DEOXY-a-0-GLUCOPYRANOSIDE ... 

To a solution of the S-(+)-4-acethoxy-9-[2-(5-ethyl-l,2,3,6-tetrahydro-pyridin-3yl)-l-(lH-indol-2-yl)-l-methoxycarbonyl-ethyl]-3a-ethyl-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,ll,12,12b-octahydro-lH-6,12a-diaza-indeno[7,l-ca]fluorene-5-carboxylic acid methyl ester in dioxane and glacial acetic acid was added 37% aqueous formaldehyde and the mixture stirred at 35°C for 24 h. The solution was evaporated in vacuo and the residue suspended in chloroform and washed with cold aqueous 5% K2C03 solution. The chloroform layer was dried (MgS04), filtered, and evaporated. The residue was chromatographed eluting with EtOAc/MeOH, 10% NH4OH to give the product navelbine. 

Carboxy-6-hydroxythiazolo[2,3-/ [ 1,6]-naphthyridin-4-ium-3-carboxylate (152) (beminamycinic acid) underwent exhaustive methylation to afford methyl 8-methoxy-6-(l-methoxycarbonyl-2-methylthiovinyl)-5-oxo-5,6-dihydro-1,6-naphthyridine-2-carboxylate (153) (Mel, Ag20 low yield)293 or hydrogenolysis to furnish a separable mixture of 6-(l-carboxylatoethyl)-8-hydroxy-l,2,3,4-tetrahydro-l,6-naphthyridin-6-ium-2-carboxylic acid (154) and 8-hydroxy-1,2,3,4-tetrahydro-l,6-naphthyridine-2-carboxylic acid (155) (Raney Ni, NaOH, H20 unstated yields).274... 

Hydrolysis of dimethyl 6-methyl-8-(3-nitrophenyl)-3-oxo-l,3,4,8-tetrahy-dropyrido[2,l-c][l,4]oxazine-7,9-dicarboxylate in MeOH in the presence of KOH at room temperature afforded 2-[2-hydroxymethyl-6-methyl-4-(3-ni-trophenyl)-3,5-bis(methoxycarbonyl)-l,4-dihydropyridin-l-yl]acetic acid (95PHA681). Hydrolysis of 7,8,9,10-tetrafluoro-l,2,4,6-tetrahydro[l,4]ox-... 

Acetyl-3-methoxycarbonyl-/ -carboline, the alkaloid of Vestia lycioides, has been synthesized by two routes 200,6 the second involves the benzylic oxidation-dehydrogenation of l-ethyl-3-methoxycarbonyl-l,2,3,4-tetrahydro-/ -carboline by means of selenium dioxide in dioxan. A by-product in this oxidation was 1 -acetyl-/ -carboline, which occurs in Ailanthus malabarica. An extension of this reaction led to a simple two-stage synthesis of canthin-6-one (22) from Ab-benzyltryptamine and a-ketoglutaric acid (Scheme 2).206... 

Methoxy-7-methoxycarbonyl-l,2,3,4-tetrahydronaphthalene 2-Naphthalene-carboxylic acid, 5,6,7,8-tetrahydro-3-methoxy-, methyl ester (10) ... 

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