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Indole 4,7-dihydro

In the case of vinylfurans and vinylpyrroles there is the possibility of cycloaddition involving either the cyclic diene system or the diene system including the double bond. 2-Vinylfuran reacts in high yield with maleic anhydride in ether at room temperature to form the adduct involving the exocyclic double bond. Similarly, 2- and 3-vinylpyrroles react with 7T-electron-deficient alkenes and alkynes under relatively mild conditions to give the corresponding tetrahydro- and dihydro-indoles (Scheme 51) (80JOC4515). [Pg.66]

Bis-[trilluoracetoxy]-borau (aus Trifluoressigsaure und Diboran)7 reduziert z.B. Indol zu 2,3-Dihydro-indol (s.S. 87). [Pg.7]

Ungesattigte Lactame werden durch Diboran hydroboriert. In 2-Oxo-3-alkyliden-2,3-dihydro-indol-Derivaten ist die C=C-Doppelbindung stark elektrophil, so daB sie mit Natriumboranat selektiv gesattigt werden kann1 ... [Pg.82]

Oxo-3-cyclohexyl-2,3-dihydro-indol Zu einer heifien Losung von 0,75 g(3,5 mMol) 2-Oxo-3-eyclohexy-liden-2,3-dihydro-indol in 40 m/ Methanol und5 ml Wasser werden unter Rtihren 0,3 g (8 mMol) Natriumboranat gegeben. Man koeht 15 Min. unter RiickfluB, dampft das Methanol ab, verdiinnt mit Wasser und filtriert Ausbeute 0,71 g (94°/0 d.Th.) F 165-167° aus Methanol umkristallisiert F 168-169°. [Pg.82]

Aus Isatin-3-hydrazon (bzw. 3-Diazo-2-oxo-2,3-dihydro-indol) entsteht in waBriger Pufferlosung 3-Amino-2-oxo-2,3-dihydro-indol4. [Pg.612]

Dimethoxy-3-(2-hydroxy-athyl)-2,3-dihydro-aus 5,6-Dimethoxy-2-oxo-3-(athoxycarbonyl-methyl)-2,3-dihydro-indol und Lithiumalanat 250... [Pg.952]

Indole-carboxylic acid 2,3-Dihydro-indole EDC Antitumor antibiotic 96 2006JA7136... [Pg.145]

N-, 2- and 2,3- alkylsubstituted indoles are reduced in acid solution to give good yields of the dihydroindolc [63]. Indole itself is polymerised under the acid conditions. Reaction was originally carried out in a medium of 60 % sulphuric acid at a lead cathode with no attempt made to find the optimum acid concentration. More recently, 20 % sulphuric acid has been proposed as the solvent in these reactions [64], Reduction of tetrahydrocarbazole 17 gives predominately cis-hexahydro-carbazole, the thermodynamically favoured isomer, along with 1 -2 % of the trans-isomer [65], 2,3-Dimethyl-indole yields a mixture of the cis- and trans-dihydro-indole isomers [63,66],... [Pg.247]

MI6). This modified cycloaddition may be used for the formation of dihydro-indole systems at cpCo [Eq.(33), where R = COOCH3]. [Pg.199]

CHO O-CO-CFj NaN02 / CuSO+/DMF 100 24 3-Formyl-4-nilro-2.3-dihydro- indol 72b 196- 198 3... [Pg.348]

H (fj j>-C00CH3 O-CO-CF, NaNOj/ CuSO DMF 2-Methoxycarbonyl-4-nitro-2,3-dihydro-indol 54 186- 187 3... [Pg.348]

Ethoxycarbonyl-2-hydroximino-ethyl) -2-oxo-2J-dihydro-indol 50% Schmp. 184° (Ethanol/Cyclohexan)... [Pg.388]

Viele Beispiele fur auf diese Weise erhaltene Aryl-dialky 1-aminc und Alkyl-aryl-amine finden sich in Lit.1. Durch analoge intramolekularc homolytische Aminierung in Ge-genwart von EisenflL-Salzen1 Oder Titan(III)-chlorid2 lassen sich 2,3-Dihydro-indole und 1,2,3,4-Tetrahydro-chinoline herstellen z.B. 1-Methyl-l, 2,3,4-tetrahydro-chino-lin (81 %)1,3 ... [Pg.657]

Der Halogen/Amin-Austausch kann bei geeigneten Substraten auch intramolekular ab-laufen unter Bildung von N-Heterocyclen, wie die Synthese von 2,3-Dihydro-indol aus 2-Amino-l-(2-chlor-phenyl)-ethan zeigt3. [Pg.686]

N0ir 0 5- CMl (Vi °l ov ch3 H2/PtQ2J H2OfH2COJC6H6 200kPa 20 25° 2h 3-Methylsulfonyloxymethyl- 2,3-dihydro-indol 80 ... [Pg.845]

Chlor-3,3-diphenyl-2-formyl-l-methyl-2,3-dihydro-indol 35%... [Pg.989]

As cyclic amines are at the heart of medicinal chemistry, there is always interest in new methods for their preparation. Marco Ciufoiini of the Universitc Claude Bernard in Lyon reports (Organic. Lett. 5 4943, 2003) the preparation of a series of dihydro indole derivatives, exemplified here by 3, 6, and 9, by free radical cyclization of an N-O precursor. The N-O precursor can be prepared from the corresponding bromide, as illustrated by the conversion of 1 to 2 and of 4 to 5. Alternatively, a radical precursor such as 8 can be prepared separately. The generated radical is then trapped by 7 to make a new radical, that cyclizcs to 9. [Pg.29]


See other pages where Indole 4,7-dihydro is mentioned: [Pg.86]    [Pg.127]    [Pg.127]    [Pg.251]    [Pg.251]    [Pg.251]    [Pg.364]    [Pg.365]    [Pg.689]    [Pg.951]    [Pg.952]    [Pg.952]    [Pg.546]    [Pg.348]    [Pg.749]    [Pg.982]    [Pg.1026]    [Pg.1137]    [Pg.1137]    [Pg.1137]    [Pg.1137]    [Pg.1137]    [Pg.1200]    [Pg.1206]    [Pg.206]    [Pg.256]    [Pg.822]    [Pg.13]    [Pg.256]    [Pg.358]    [Pg.702]   


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1.2- Dihydro-3//-benzo indoles

2.3- Dihydro-1 //-indole-2-sulfonic acid

Benz indole, 4,5-dihydro

Benzo indole 1.2- dihydro

Indol-4 -ones, 6,7-dihydro indoles

Indole, 1-acetyl-2,3-dihydro-7-hydroxysynthesis

Indoles 2,3-dihydro— from

Indoles 2.3- dihydro

Pyrrolo indol-3 -ones 1.4- dihydro

Pyrrolo indoles, dihydro

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