Methods in Organic Synthesis

The overall result of the sequence hydroboration -I- oxidation is a regioselective and-Markownikoff-addition of water to an alkene. This reaction is an important method in organic synthesis, since it can be made stereoselective and even enantioselective. 

The synthetic importance of the malonic ester synthesis follows from the fact that the substituted malonic ester can easily be hydrolyzed, and subsequently decarboxylates to yield a substituted acetic acid 9. This route to substituted acetic acids is an important method in organic synthesis ... 

The Peterson olefination is a quite modern method in organic synthesis its mechanism is still not completely understood. " The a-silyl organometallic reagent 2 reacts with the carbonyl substrate 1 by formation of a carbon-carbon single bond to give the diastereomeric alkoxides 4a and 4b upon hydrolysis the latter are converted into /3-hydroxysilanes 5a and 5b ... 

B. J. Wakefield, Organomagnesium Methods in Organic Synthesis, Academic Press, London, 1995. 

J.R. Dean, L. Fitzpatrick and C. Heslop, in Extraction Methods in Organic Synthesis (AJ. Handley, ed.), Sheffield Academic Press/CRC Press, Sheffield (1999), pp. 166-93. 

Microwave Methods in Organic Synthesis Volume Editors Larhed, M., Olofsson, K. 

As discussed previously, radical ring-opening reactions of three-membered systems via cyclopropylmethyl and oxiranylmethyl radicals represent a fruitful method in organic synthesis [111]. De Kimpe and coworkers have now shown that azirid-ines can also be used, featuring a radical one-step synthesis of pyrrolizidines 3-280... 

Beginning as chemical curiosities, carbenes are now solidly established as reactive intermediates with fascinating and productive research areas of their own. Six decades of divalent carbon chemistry have provided us with a vast repertoire of new, unusual, and surprising reactions. Some of those reactions, once classified as exotic, have become standard methods in organic synthesis. These highly reactive carbene species have been harnessed and put to work to achieve difficult synthetic tasks other reactive intermediates cannot easily perform. 

In addition, there are an increasing number of methods in organic synthesis that involve C-C bond formation, oxidation, and reduction. Although these methods have been discussed in the previous chapters according to their categories, it would perhaps be desirable to detail them in the second part of this chapter. With the steady increase in the number of publications, some of the most advanced methodologies need to be classified, and this last chapter is the logical place for their inclusion. 

RC Sheppard. Continous flow methods in organic synthesis. Chem Britain 402, 1983. 

I 3 Comparison of Chemical and Electrochemical Methods in Organic Synthesis... 

Tundo, P. Continuous Flow Methods in Organic Synthesis, Horwood, Chichester, UK, 1991. 

Yves Chauvin France development of the metathesis method in organic synthesis... 

The aldol reaction is one of the most fundamental and useful synthetic methods in organic synthesis and boron enolates are known (18) to be the most efficient intermediates in view of their mild reaction conditions and high stereoselectivity. Recently, stannous enolates... 

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