Methodology multiple sclerosis

Feinstein A. Multiple sclerosis, disease modifying treatments and depression a critical methodological review. Mult Scler 2000 6(5) 343-8. 

Henderson, W.G., TourteUotte, W.W., Potvin, A.R., and Rose, A.S. 1978. Methodology for analyzing clinical neurological data ACTH in multiple sclerosis. Clin. Pharmacol. Ther. 24 146. 

In summary, the substrate-directed Heck-Matsuda reaction was successfully applied for the synthesis of polyfunctionalized cyclopentenes under very mild conditions. The method is very robust, and aryldiazonium salts with distinct electronic or steric properties were well tolerated. The power of this methodology was demonstrated by the total synthesis of the VPC01091 (130), an agonist of the SlPi receptor, a potential new drug for the treatment of multiple sclerosis. ... 

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