Methodological detection limits definition

Apart from the points discussed above, some other aspects should also be addressed so that CE can be used as a routine method in this field. These include the development of new chiral selectors and detector devices. The nonreproducibility of the methods may be due to the heating of the BGE after a long run of the CE machine. Therefore, to keep the temperature constant throughout experiments, a cooling device should be included. There are only a few reports that deal with method validation. To make the developed method more applicable, the validation of the methodology should be determined. Chiral capillaries should be developed and the CE machine should be coupled with a mass spectrometer and with polarimetric and circular dichroism detectors, which may result in good reproducibility and low detection limits. Not all of the capabilities and possibilities of CE as a chiral resolution technique have been explored as yet, and a lot of work remains to be done to advance the use of CE for the chiral resolution of environmental pollutants. CE will definitely prove itself as the best technique within the coming few years, and it will achieve a reputable status as a technique for routine analysis in most enviromnental laboratories. 

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