Methionine decarboxylase

Two-dimensional structures of 2 -deoxy-2 -(3-methoxybenzamido) adenosine (MMBA), a selective T.brucei GAPDH inhibitor and MDL 73811, an irreversible inhibitor of trypanosomal S-adenosyl methionine decarboxylase. 

Lysine is formed in bacteria by decarboxylation of meso-diamino-pimelic acid (Fig. 24-14). Glycine is decarboxylated oxidatively in mitochondria in a sequence requiring lipoic acid and tetrahydrofolate as well as PLP (Fig. 15-20). A methionine decarboxylase has been isolated in pure form from a fem. ° The bacterial dialkylglycine decarboxylase is both a decarboxylase and an aminotransferase which uses pyruvate as its second substrate forming a ketone and L-alanine as products (See Eq. 

Wrenger, C., Luersen, K., Krause, T., Muller, S., and Walter, R. D. (2001). The Plasmodium falciparum bifunctional ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase, enables a well balanced polyamine synthesis without domain-domain interaction. ]. Biol. Chem. 276,29651-29656. 

Using a similar experimental strategy, the pyruvyl-dependent S-adenosyl-methionine decarboxylase Escherichia coli) was also demonstrated to involve retention of configuration at the a-carbon of the methionyl moiety (269). The... 

Tekwani, B. L., Bacchi, C. J. and Pegg, A. E. (1992) Putrescine activated S-adenosyl-methionine decarboxylase from Trypanosoma brucei brucei. Mol. Cell. Biochem. 117 53-61. 

The aromatic diamidines are compounds of considerable pharmaceutical interest. This is, among others, for the following reasons they have a strong antiprotozoan action and participate in the metabolism and transport of polyamines, inhibiting, for instance, 5-adenosyl-L-methionine decarboxylase (SAMDC). Therefore, because this route is closely linked to cell proliferation processes, aromatic diamidines can slow down or prevent the growth of tumors. The substances used in this work are as follows " ... 

Fig. 194. Formation of spermidine and spermine 1 S-Adenosyl-L-methionine decarboxylase 2 aminopropyltransferase...

Gomez-Jimenez M, Paredes M, Geillardo M, Femandez-Garda N, Ohnos E, Sanchez-CaUe I (2010) Tissue-specific expression of olive S-adenosyl methionine decarboxylase and spermidine synthase genes and polyamine metabolism during flower opening and eady fruit development. Planta (Bed) 232 629-647... 

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