Methanol—continued

Direct fuel appHcations of methanol have not grown as anticipated (see Alcohol fuels). It is used in small quantities in California and other locations, primarily for fleet vehicle operation. Large-scale use of methanol as a direct fuel is not anticipated until after the year 2000. Methanol continues to be utilised in the production of gasoline by the Mobil methanol-to-gasoline (MTG) process in New Zealand. A variant of this process has also been proposed to produce olefins from methanol. 

Fig. 3.1.2 The apparatus used in 1956 for the methanol extraction of Cypridina luciferin. The dried Cypridina (500 g) is extracted at a temperature lower than 40°C with refluxing methanol under reduced pressure for two days. The atmosphere inside the apparatus is completely replaced with hydrogen gas that was purified by its passing through a quartz tube containing red-heated copper fragments. The temperature of the mantle heater is adjusted, the system evacuated, and then all stopcocks are closed. The extraction with refluxing methanol continues for many hours without any further adjustment. From the author s 1957 notebook.

Extraction Fluid C02 only C02+2ml methanol f static method) C02+5% methanol (continuous method)... 

The synthesis of new quinoline methanols,13,14 phenanthrene methanols,15,16 and naphthalene methanols continued, aimed at finding compounds of high activity and low phototoxicity. Against Plasmodium berghei in mice, II was active at 2.5 mg/kg and phototoxic at 100 mg/kg III was the most active of the benzoquinolines but its phototoxicity was not determined. Among the phenanthrene methanols, IV was active at 20 mg/kg and V at 1.25 mg/kg. The naphthalene methanol VI was curative against P. berghei in mice at 10 mg/kg. Phototoxicity appeared to be absent from the series. 

Isolation of Product Add 1.4 mL of cold methanol with stirring (glass rod), and then cool the mixture in an ice bath for 5-10 min. Collect the dark crystals by filtration under reduced pressure using a Hirsch funnel. Rinse the reaction vial and crystals with a few drops of cold methanol. Continue dropwise addition of cold methanol to the crystals on the filter bed until the product appears purple and is no longer brownish in color. Finally allow the crystalline product to air-dry on a porous clay plate (or in an oven at about 80 °C for 1 h) ( ). 

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