Methane monooxygenase mechanism

STUDIES OF THE SOLUBLE METHANE MONOOXYGENASE PROTEIN SYSTEM STRUCTURE, COMPONENT INTERACTIONS, AND HYDROXYLATION MECHANISM... 

Basch, H., Mogi, K., Musaev, D. G., Morokuma, K., 1999, Mechanism of the Methane —> Methanol Conversion Reaction Catalyzed by Methane Monooxygenase A Density Functional Study , J. Am. Chem. Soc., 121, 7249. 

Metalloenzymes with non-heme di-iron centers in which the two irons are bridged by an oxide (or a hydroxide) and carboxylate ligands (glutamate or aspartate) constitute an important class of enzymes. Two of these enzymes, methane monooxygenase (MMO) and ribonucleotide reductase (RNR) have very similar di-iron active sites, located in the subunits MMOH and R2 respectively. Despite their structural similarity, these metal centers catalyze very different chemical reactions. We have studied the enzymatic mechanisms of these enzymes to understand what determines their catalytic activity [24, 25, 39-41]. 

Studies of the Soluble Methane Monooxygenase Protein System Structure, Component Interactions, and Hydroxylation Mechanism Katherine E. Liu and Stephen J. Lippard... 

Basch, H., Musaev, D.G., Mogi, K. and Morokuma, K. (2001 a) Theoretical studies on the mechanism of the methane —> methanol conversion reaction catalyzed by methane monooxygenase O-side vs N-side... 

Yoshizawa, K. (2000) Two-step concerted mechanism for methane hydroxylation on the diiron active site of soluble methane monooxygenase, J. Inorg. Biochem. 78, 23-34. 

Jin, Y., and Lipscomb, J. D., 1999, Probing the mechanism of C6H activation oxidation of methylcubane by soluble methane monooxygenase from Methylosinus trichosporium OB3b, Biochemistry 38 6178n6186. 

Shteinman, A. A., 1995, The mechanism of methane and dioxygen activation in the catalytic cycle of methane monooxygenase, FEES Lett. 362 5n9. 

We consider briefly the structure and mechanism of action of soluble MMO (sMMO), the best characterized of the BMMs (bacterial methane monooxygenases) (Figure 13.27), which is able to activate the inert C—H bond of... 

Scheme 6-6 Proposed mechanism for the activation of O2 by methane monooxygenase (M.MO) for the monooxygenation of hydrocarbons (RH)...

Siegbahn PEM, Crabtree RH (2000) Quantum Chemical Studies on Metal-Oxo Species Related to the Mechanisms of Methane Monooxygenase and Photosynthetic Oxygen Evolution. 97 125-144... 

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