Methanamine, A-methyl

The polymorphism encountered with l-(5- [(2R,3S)-2-( (lR)-l-[3,5-Bis(trifluoromethyl)phenyl] ethyl oxy)-3-(4-fluorophenyl)morpholin-4-yl]methyl -2H-l,2,3-triazol-4-yl)-A,A-dimethyl-methanamine hydrochloride (Compound A, hereafter), a high-affinity, orally active h-NKl receptor antagonist (Harrison et al. 2001), illustates the complexity of solid phase behavior. 

S-methanamine, 4-amino-1-methyl-, phosphate (1 1) -4-methanamine, S-(dimethylamino)-N,N,a-tiimethyl-... 

Taber, G. P. Pfisterer, D. M. Colberg, J. C. A New and Simplified Process for Preparing N-[4-(3,4-Dichlorophenyl)-3,4-dihydro-l(2H)-naphthalenyl-idene]methanamine and a Telescoped Process for the Synthesis of (IS-cis)-4-(3,4-Dichlorophenol)-1,2,3,4-tetrahydro-N-methyL 1 -naphthalenamine Mandelate Key Intermediates in the Synthesis of Sertraline Hydrochloride. Org. Proa Res. Dev. 2004, [Pg.431]

It should be noted that amine is used as a suffix that has been added to the name of the alkyl group. That is, unlike the functional group name alcohol, which is a separate word, for example, methyl alcohol, or the functional group name, ether, as in methyl ether, the functional group name amine, is appended directly to that of the alkyl substituent, that is, methanamine. 

If only one hydrogen atom in ammonia has been replaced then a primary amine is formed. For example, methanamine or methylamine (Figure 10.40a) - note that it is acceptable to use either prefix, methan or methyl. 

Readily available chiral amines related to the Betti base [phenyl(2-hydroxy-l-naphthyl)methanamine] catalyse enantioselective addition of diethylzinc to aldehydes in moderate to excellent ee Observed enantioselectivities in addition of diethylzinc to aldehydes catalysed by a series of (5)-proline-derived pyrrolidines have been explained in terms of steric effects. New 2,5-diazabicyclo[2.2.1]heptanes have been applied to enantioselective addition of diethylzinc to benzaldehyde. (S)-2-(3-Methyl-2-pyridyl)-3,5-di-r-butylphenol (76) has been used as an enantioselective catalyst of diethylzinc addition to benzaldehydes. Reaction in toluene shows a significant variation in % ee with temperature, including observation of an inversion temperature with maximum ee. This value varies with the nature of the para-substituent in the aldehyde, and the overall behaviour may be due to a shift in the rate-determining step of the reaction. Other reports of zinc reagents include enantioselective addition of diethylzinc to aldehydes addition of diphenylzinc to aldehydes using a chiral ferrocene-based hydroxyoxazoline catalyst in up to 96% ee and 3-exo-morpholinoisoborneol has been proposed as a more convenient and efficient enantioselective catalyst of alkylzincs than Noyori s original 3-exo-dimethylamino catalyst. ... 

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