Methampyrone-phenylbutazon

Figure 2. (a) The contact area of methampyrone-phenylbutazon indicated peritecticum mixture (1) before heating, (2) phenylbutazon melted at 105°C, (3) contact area-1 melted at 119°C, (4) contact area-2 melted at 140°C, (5) contact area-3 melted at 150°C, and (6) methampyron melted followed by oxidation at 22Q-230°C. (b) DSC data of phenylbutazon (top), methampyrone (middle), and the mixture of methampyrone-phenybutazon 7 3 weight ratio. 

The results prove strong relation between cold contact method data and DSC. The simple eutectic interaction of pseudoephedrine hcl-acetaminophen, the peri-tectic interaction between methampyrone-phenylbutazon, and solid solution formation between amoxicillin trihydrate-clavulanate have been early detected by this simple method. Therefore, this method has high possibility to be used as a simple method to evaluate the other drug interactions [10—13]. 

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