Cold contact method

The Cold Contact Method as a Simple Drug Interaction Detection 162 System... 

The results prove strong relation between cold contact method data and DSC. The simple eutectic interaction of pseudoephedrine hcl-acetaminophen, the peri-tectic interaction between methampyrone-phenylbutazon, and solid solution formation between amoxicillin trihydrate-clavulanate have been early detected by this simple method. Therefore, this method has high possibility to be used as a simple method to evaluate the other drug interactions [10—13]. 

The acceptability of the cold contact method as a simple method to identify the physical interaction of drug combination has been proved by coherency between the cold contact method data with the DSC evaluation. 

I. Nugrahani, S. N. Soewandhi, S. Asyarie, and S. Ibrahim, The cold contact method to detect physical interaction of amoxicillin-clavulanate, in Proceeding of International Chemical Conference and Seminar, Yogyakarta, Indonesia, 2007. 

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