Methamphetamines methylated action

Methamphetamine Hydrochloride. Methampheta-mine, (-( )-1 -phenyl-2-methyiaminopropane hydrochloride desoxyephedrine hydrochloride (Dcsoxyn). is the N-methyl analogue of dextroamphetamine. It has more marked central and lc.ss peripheral action than dextroamphetamine. It has a very high abuse potential, and by the intravenous route, its sails are known as .speed." The overall abu.se problem presented by the drug is a national disaster. Medicinally acceptable u.scs of methamphetamine are analogous to tliose of dextroamphetamine. 

A closely related agent is PMMA, or N-methyl-1-(4-methoxyphenyl)-2-aminopropane. PMMA is a hybrid structure of two phenylisopropylamine stimulants PMA, and methamphetamine (Fig. 23.6) Surprisingly, PMMA lacks significant central stimulant actions, and unlike PMA and methamphetamine, PMMA is not recognized by (+)-amphetamine-trained animals. Because PMMA is structurally related to metabolites of MDMA, it was examined in MDMA-trained animals and found to be several-fold more potent than MDMA. Animals have been trained to discriminate PMMA from vehicle, and PMMA stimulus generalization occurred to ( )-MDMA and S-(+)-MDMA, but not to DOM,... 

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