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Methadone:naloxone combination

A 10 1 methadone naloxone combination evaluated In man provoked few side effects,° advancing to clinical trials the previously described concept of using a parenterally effective antagonist combined with an oredly active narcotic to prevent abuse of oral medication. ... [Pg.11]

The addition of 1 mg of naloxone to 100 ml of paregoric 230 produces a product which is indistinguishable from paregoric alone when taken orally as intended. When boiled down, filtered, and injected, however, the combination will produce abstinence in the dependent subject, as does the methadone-naloxone. Other agonists are also being combined with naloxone to deter oral abuse (e.g. oxycodone). [Pg.43]

The approval of buprenorphine for the office-based treatment of opioid dependence represents a major departure from the earlier methadone clinic system. Physicians with addiction specialist credentials or those who have completed 8 hours of approved training can become qualified to treat up to 30 patients in their private offices. Stable patients may be given prescriptions for up to a month of medication. The combination buprenorphine/naloxone tablet is expected to have minimal risk for diversion. When taken subhnguaUy, as prescribed, naloxone has minimal biologic activity and does not interfere with the buprenorphine dose. However, if an attempt is made to inject the drug, the addict will experience the full antagonist effect of the naloxone. [Pg.83]

Sublingual buprenorphine is an alternative to methadone in treating opiate dependence, but its opioid agonist effects pose the risk of intravenous abuse and subsequent dependence. This abuse potential may be hmited by using a combination of buprenorphine with naloxone, which will precipitate opiate withdrawal when given... [Pg.572]

Administration (FDA) for the treatment of opioid addiction. Treatment is initiated with buprenorphine alone administered sublingually, followed by maintenance therapy with a combination of buprenorphine and naloxone (Suboxone) to minimize abuse potential. The partial agonist properties of buprenorphine limit its usefulness for the treatment of addicts who require high maintenance doses of opioids. However, conversion to maintenance treatment with higher doses of methadone, a full agonist, is possible. [Pg.115]

LIVER A long-term study of patients with hepatitis C who were randomised to buprenorphine versus methadone for long-term pain control did not show any adverse elevation to transaminases over a 4-week period [85 -]. The combination product buprenorphine/naloxone, however, was associated with an elevated aminotransferase in 25/150 (17%) HIV-negative patients over 4 weeks in a different study [86 ]. [Pg.113]

Persky and Goldfrank (43 ) reviewed 86 methadone overdose cases in 81 patients all treated successfully with intravenous naloxone hydrochloride. Four patients had pulmonary oedema. In more than half, liver and muscle function studies showed abnormalities. 79 of the overdoses were associated with a combination of methadone and other non-opiate drugs, including alcohol. Cameron (9") described grossly depressed respiration after morphine, metoclopramide and naloxone were given in sequence. [Pg.60]


See other pages where Methadone:naloxone combination is mentioned: [Pg.165]    [Pg.43]    [Pg.81]    [Pg.94]    [Pg.538]    [Pg.702]    [Pg.522]    [Pg.151]    [Pg.134]   
See also in sourсe #XX -- [ Pg.11 ]




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