Methadone maintenance therapy

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. Cochrane Database Systematic Reviews, 4... 

Mattick RP Hall W (1996). Are detoxification programmes effective. Lancet, 347, 97-100 Mattick RP, Ali R, White JM, O Brien S, Walk S Danz C (2003). Buprenorphine versus methadone maintenance therapy a randomized double-blind trial with 405 opioid-dependent patients. Addiction, 98, 441-52 Mattick RP, Kimber J, Breen C Davoli M (2004). Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence (Cochrane Review). The Cochrane Library, issue 2. Chichester, UK John Wiley Sons... 

Manfredi PL, Gonzales GR, Cheville AL, Kornick C, Payne R. Methadone analgesia in cancer pain patients on chronic methadone maintenance therapy. J Pain Symptom Manage 2001 21(2) 169-74. 

Constant Methadone Levels in Hair in Methadone Maintenance Therapy... 

Following a report of withdrawal symptoms in three patients taking methadone maintenance therapy, serum methadone concentrations were measured before and after starting efavirenz in one patient (26). Serum methadone concentrations were as follows (R)-methadone (the active enantiomer) 168 ng/ml and 90 ng/ml before and after efavirenz. The corresponding (5)-methadone concentrations were 100 and 28 ng/ml. The dosage of methadone was increased from 100 to 180 mg/day before the patient s withdrawal symptoms resolved. 

Since methadone is partly metabolized by CYP3A4, the interaction of efavirenz with methadone has been investigated prospectively in 11 patients taking stable methadone maintenance therapy (28). Efavirenz reduced the steady-state methadone AUC by 50%. However, patients generally only needed a 22% increase in their methadone dose to eliminate the symptoms of methadone withdrawal, and the full basis of the interaction is not understood. 

Methadone maintenance therapy is effective against heroin and other opiate dependence. Methadone, a synthetic analgesic, is pharmacologically equivalent to opiates and gradually substitutes for the abused drug. It saturates the opiate receptors. This substance is addictive too the addictive potential, however, is lesser and milder than that associated... 

A patient receiving methadone maintenance therapy (30 mg daily) was successfully and uneventfully treated for depression with tranylcypromine, initially 10 mg daily gradually increased to 30 mg daily... 

Jamois C, Smith P, Morrison R, Riek M, Patel A,. Schmitt C, Morcos PN, Zhang X. Effect of saquinavir/ritonavir (1000/100 mg bid) on the pharmacokinetics of methadone in opiate-dependent HIV-negative patients on stable methadone maintenance therapy. Addict Biol 2009 14 321-7. 

RESPIRATORY Chronic methadone maintenance therapy in a child with acute myeloid leukaemia who developed chemotherapy-induced renal insufficiency likely led to inadequate clearance of methadone and methadone-induced respiratory depression and central sleep apnoea [47" ]. 

---