Methacrylated dextran release

Chen FM, Zhao YM, Sun HH, Jin T, Wang QT, Zhou W, Wu ZF, Jin Y (2007) Novel gly-cidyl methacrylated dextran (dex-gma)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins formulation and characteristics. J Control Release 118(1) 65—77... 

Microparticles of acidic and basic gelatin were used as carriers for the individual delivery of two different growth factors and were embedded in a hydrogel matrix, composed of glycidyl methacrylated dextran (Dex-GMA)/gelatin. This hybrid system allowed the independent release of BMP-2 or IGF-1 that facilitated cell attachment, proliferation, metabolism, and osteoblastic differentiation of cells in a synergistic manner [127]. 

Jiang and Zhu (2000) and Qiu and Zhu (2001) have reported the fabrication of multilayered devices composed of stacks of compression-molded disks of alternating compositions. One type of disk is either P(SA-EG) or P[SA-co-TMAgly)-Z>-EG] and the other is a pH-sensitive, protein-loaded blend of, for example, poly(methacrylic acid) and polyethoxazoline. The release of model proteins, myoglobin, bovine serum albumin, and FITC-dextran, and compounds such as brilliant blue have been studied and pulsatile release profiles have been demonstrated (Jiang and Zhu, 2000 Qiu and Zhu, 2001). 

This chapter deals with the layer-by-layer (LbL) assembly of polyelectrolyte multilayers of polypeptides (poly L-ly sine/poly L-glutamic acid) and polysaccharides (chitosan/dextran suliate) onto soft and porous thermo-responsive poly (N-isopropylacrylamide-co-methacrylic acid) (P(NiPAM-co-MAA)) nanogels. The formation of the LbL structures and characterization of hydro-dynamic radius, electrophoretic mobility, bilayer thickness and stability over time of the systems will be comparatively discussed. Further, the assembly of biopolymers onto similar microgels will be analyzed. The results presented demonstrate that the structure and properties of biocompatible multilayer films can be finely tuned by confinement onto soft and porous gels, which provides new perspectives for biomedical plications, particularly storage and controlled release of biomolecules. 

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