Metastasis clinical manifestations

The clinical dilemmai is that by the time a primary tumor is detected and surgically removed, the metastatic process may have already been ongoing for a considerable period of time. In fact, the spread of metastatic colonies is frequently well underway before clinical symptoms of metastasis are evident, in some cases even before symptoms of the primary tumor are manifest. Our ability to detect presymptomatic tumors—primary or... 

Metastatic Dissemination of Tumour Cells 118 Clinical Courses and Experimental Data from Primary Tumours and Metastases Do Not Enable a Coherent Understanding of Metastatic Progression 118 Studying the Precursor Cells of Metastasis 120 Dissemination Can Be an Early Event in Malignant Cancers 120 Genetic Heterogeneity During Minimal Residual Disease 120 Clonal Expansion of Disseminated Tumour Cells Occurs Shortly Before Manifestation of Metastasis 121... 

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