Metalloenzymes models

Tripodal N V,0-Ligands for Metalloenzyme Models and Organometallics Nicolai Burzlaff... 

TRIPODAL A, A, 0-LIGANDS FOR METALLOENZYME MODELS 151 VII. Immobilization of N,N,0 Complexes... 

Enzyme models 18 and 19, which catalyze the decarboxylation, are typical examples of double recognition (87). These metalloenzyme models recognize a-ketoacid as the specific substrate by the hydrophobic interaction and coordination interaction as shown in Fig. 24 and Table XVII. Thus, the presence of the second recognition site, triamino-Zn2+, results in an increase... 

In Section 3 cooperative function of non-metalloenzyme model polymer will be discussed from several points of view. The cooperative function can be observed not only in the catalyst for hydrolysis but also in the catalyst for the synthesis. 

Reports which have clear applications in DNA hydrolysis include one of a dinuclear lanthanum(III) complex that catalyses phosphate diester hydrolysis to give unprecidented rates of reaction and one describing the preparation of two new dinuclear bisimidazolyl-Cu(II) calixarenes and an investigation of these complexes as metalloenzyme models for phosphate diester cleavage. The importance of tuning microenvironments when designing synthetic nucleases is illustrated by a report that intramolecular trans-esterification of 2-hydroxy-propyl-4-nitrophenyl phosphate (84) is up to 5000 times faster in organic solvents than in water/ ... 

Kraatz, H.-B. and Metzler-Nolte, N. (eds) (2006) Concepts and Models in Bioinorganic Chemistry, John Wiley Sons, Ltd, Chichester, UK. A broad student-focussed coverage of the field of bioinorganic chemistry, which includes metalloenzyme model coordination chemistry individual chapters are authored by experts in their field to a standard pattern that gives the book cohesion and good readability. 

---