Metallo-phosphodiesterase models

Calix[4]arenes as dinuclear metallo-phosphodiesterase models 00CSR75. 

P. Molenveld, J. E. J. Engbersen, D. N. Reinhoudt, Dinuclear metallo-phosphodiesterase models apphcation of calix[4]arenes as molecular scaffolds, Chem. Soc. Rev., 2000, 29, 75-86. 

The first dinucleotide cleavage with the trinuclear zinc complex was reported shortly afterwards pseudo-first order rate constants were determined and a pronounced selectivity for the 3, 5 -GpG RNA homodinucleotide was discovered [87]. These new dinuclear metallo-phosphodiesterase models were reviewed in 2000, and compared with other less efficient existing models [88]. 

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