Metallo-beta-lactamase inhibitors

R. Nagano, Y. Adachi, H. Imamura, K. Yamada, T. Hashizume, H. Morishima, Car-bapenem Derivatives as Potential Inhibitors of Various beta-Lactamases, Including Class B Metallo-beta-Lactamases , Antimicrob. Agents Chemother. 1999, 43, 2497-2503. 

Chromosomal metallo-beta-lactamases that hydrolyze carbapenem antibiotics, such as imipenem, meropenem, or biapenem, are present in some Stenotro-phomonas, Bacteroides, andAeromonas strains [26], Some clinical/5, aeruginosa and Serratia marcescens isolates have a plasmid that carries metallo-beta-lactamase genes [26], These enzymes are not inactivated by inhibitors of serine-based beta-lactamases such as clavulanic acid or sulbactam analogs. Enzyme-... 

R Nagano, Y Adachi, H Imam lira, K Yamada, T Hashizume, H Morishima. Carba-penem derivatives as potential inhibitors of various beta-lactamases, including class B metallo-beta-lactamases. Antimicrob Agents Chemother 43 2497-2503, 1999. 

JH Toney, PM Fitzgerald, N Grover-Sharma, SH Olson, WJ May, JG Sundelof, DE Vanderwall, KA Cleary, SK Grant, JK Wu, JW Kozarich, DL Pompliano, GG Hammond. Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase. Chem Biol 5 185-196, 1998. 

Sanschagrin, F., Levesque, R. C. (2005). A specific peptide inhibitor of the class B metallo-beta-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display. J. Antimicrob. Chemother., 55, 252-255. 

J. Antony, J. P. Piquemal, and N. Gresh, /. Comput. Chem., 26(11), 1131-1147 (2005). Complexes of Thiomandelate and Captopril Mercaptocarboxylate Inhibitors to Metallo-Beta-Lactamase by Polarizable Molecular Mechanics Validation on Model Binding Sites by Quantum Chemistry. 

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