Metal-sugar complexes stability constants

In the previous chapters the reactivity of metal ions with the monomer units of nucleic acids has been discussed. This section will deal with the binding of transition metals to the polynucleotides. There are also three types of complexes to be expected the metal-ring, the intermediate and the metal chain complex. The effect of the ribose or deoxyribose residue on the stability constants can be neglected since the reactivity of these sugars with cations is extremely low. However, as it will be seen later, the hydrolysis of polyribonucleotides is markedly facilitated by interaction of metal ions with the 2 —OH groups of the ribose. 

The methods of synthesis of uronic acids by catalytic and nonspecific oxidation of sugars has been reviewed,and a study of the oxidation of octyl a-D-glucopyranoside to octyl a-o-glucopyranosiduronic acid by sodium hypobromite catalysed by some ruthenium complexes has been reported. The stability constants of metal ion-uronic acid complexes have been reviewed. ... 

Stability constants of metal complexes, ix Stoicheiometnc concentration (defined), 18 Sugars, pK, values. 86 Sulphinic acids. pK., values, 88 Sulphonic acids, pK values, 88 Sulphur acids ( meicaptans), 8 ->... 

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