Metal ion dependent adhesion site

Bienkowska J, Cruz M, Atiemo A, Handin R, Liddington R The von willebrand ctor A3 domain does not contain a metal ion-dependent adhesion site motif. J Biol CSiem 272 25162-25167,1997... 

Recent studies indicate that a limited region of GPIIIa (V275GSDNH280) (58) expressed in an extended loop of the metal ion-dependent adhesion site appears to involved in heterodimer assembly. In addition, the expression of isolated residues 1-233 of GPIIb and 111 -318 of GPIIIa leads to the formation of soluble peptide heterodimers that recognize the RGD sequence (58). 

TRAP is found in the micronemes and on the surface of the sporozoite and is involved in gliding (Kappe et al., 2004b). TRAP contains two extracellular domains that bind to cellular receptors the transmembrane A-domain has a metal ion-dependent adhesive site (MIDAS) able to interact with putative sporozoite receptors such as laminin and collagen... 

Surface modification of a polymer prior to metallization is widely used to improve adhesion. The most common surface modifications employed are electric discharge (corona and plasma) and, more recently, ion-beam treatments QJ- Several mechanisms have been proposed for the improved adhesion after such surface modifications (2). These include mechanical interlocking, the elimination of weak boundary layers, electrostatic attractions, and chemical bonding. All of these can play a role in adhesion depending on the surface modification used, metal/polymer system, type of metal deposition, and the extent of polymer preparation employed. However, for low power, short exposure modifications, the formation of new chemical species which can provide nucleation and chemical bonding sites for subsequent overlayers is considered to be of prime importance (3-51. 

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