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Metal-based Chemotherapeutic Drugs

Chemotherapy is the use of drugs to injure an invading organism without injury to the host. This definition therefore covers the antibacterial, antiviral and anticancer agents. In the first two, the invading organism is clearly distinct from the host. In the case of cancer, a family of diseases characterized by uncontrolled cellular proliferation, the organism is strictly not different but the treatment has a common aim, that of elimination of the unwanted cells. Thus, chemotherapeutic [Pg.6]

Many common antibacterial agents are silver- and mercury-based - such as silver sulfadiazene and mercurochrome. Their uses and purported mechanisms have been summarized in a previous monograph and will not be presented in great length in this volume. [Pg.7]


There is a growing interest in metal-based chemotherapeutic drugs and radiopharmaceuticals, as well as in metol-chelators that nmy control metal-ion trafficking or inhibit specific metalloenzymes.(40-44) A number of metal-con5>lexes have been reported to have activity against melanoma,(4J-iO) thus the proven metal-sensitivity of melanoma suggests it may be a likely target of other lipophilic metal complexes and chelators. [Pg.408]

Fig. 13.2 Two- and three-dimensional structures of platinum-based chemotherapeutic drugs. Cisplatin, the first of the so-caUed organoplatinum drugs, contains no organic component. It is a metal coordination compound with a square-planar platinum (II) center coordinated to two ammonia and two chlorine ligands in a cw-ligand conformation. Carboplatin contains the CM-Pt(NH )2 active group... Fig. 13.2 Two- and three-dimensional structures of platinum-based chemotherapeutic drugs. Cisplatin, the first of the so-caUed organoplatinum drugs, contains no organic component. It is a metal coordination compound with a square-planar platinum (II) center coordinated to two ammonia and two chlorine ligands in a cw-ligand conformation. Carboplatin contains the CM-Pt(NH )2 active group...
Transition-metal based compounds constitute a discrete class of chemotherapeutics, widely used in medicine as antitumor agents.56 Several ruthenium complexes enable the body to catalyze oxidation and reduction reactions, depending on the physiological environment, and have attracted much interest as alternative antitumor drugs in the treatment of cancer cells resistant to cisplatin in cancer... [Pg.347]

Many metal complexes have been shown to possess bioactivity and several drugs based on metal complexes have been developed. These include platinum, gold, and bismuth compounds used in the treatment of certain kinds of cancer, arthritis, and stomach ailments, respectively [82]. The development of analogous polymeric chemotherapeutic materials, that would less easily diffuse through membranes, is also an important objective. [Pg.22]


See other pages where Metal-based Chemotherapeutic Drugs is mentioned: [Pg.6]    [Pg.6]    [Pg.550]    [Pg.140]    [Pg.445]    [Pg.2]    [Pg.21]    [Pg.250]    [Pg.2]    [Pg.522]    [Pg.2]    [Pg.6]    [Pg.275]    [Pg.113]    [Pg.371]    [Pg.577]    [Pg.146]    [Pg.264]    [Pg.446]   


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